Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

被引：79

作者：

Arnold, LD

Calderwood, DJ

Dixon, RW

Johnston, DN

Kamens, JS

Munschauer, R

Rafferty, P

Ratnofsky, SE

机构：

[1] BASF Pharma, Nottingham NG1 1GF, England

[2] BASF Biores Corp, Worcester, MA 01605 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(00)00441-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of lck in vitro; some compounds are selective for lck over src. Data are shown for two compounds demonstrating that they are potent and selective inhibitors of IL2 production in cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2167 / 2170

页数：4

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[2]

CALDERWOOD DJ, Patent No. 6001839

[3]

Coligan JE, 1998, CURRENT PROTOCOLS IM

[4] DEVELOPMENT OF SOLID-PHASE ENZYME-LINKED IMMUNOSORBENT ASSAYS FOR THE DETERMINATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND PP60C-SRC TYROSINE PROTEIN-KINASE ACTIVITY [J].