New approach to treat methicillin resistant Staphylococcus aureus with the application of boric acid

被引:3
作者
Asghari-Sana, Farzin [1 ,2 ]
Khoshbakht, Saba [3 ]
Azarbayjani, Anahita Fathi [4 ]
机构
[1] Urmia Univ Med Sci, Solid Tumor Res Ctr, POB 5714783734, Orumiyeh, Iran
[2] Urmia Univ Med Sci, Sch Pharm, Dept Pharmaceut, POB 5715799313, Orumiyeh, Iran
[3] Koc Univ, Grad Sch Hlth Sci, Istanbul, Turkey
[4] Urmia Univ Med Sci, Urmia, POB 5715799313, Orumiyeh, Iran
关键词
Boric acid; Cefotaxime; Methicillin-resistant Staphylococcus aureus; Poly vinyl alcohol; Ethyl cellulose; POLYVINYL-ALCOHOL; IN-VITRO; POLYMERIC NANOFIBERS; CRYSTAL-STRUCTURE; ETHYL CELLULOSE; CROSS-LINKING; DRUG-RELEASE; MICROPARTICLES; COMBINATION; FORMULATION;
D O I
10.1016/j.jddst.2021.103006
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Antibiotic resistance is a global concern and a heavy burden worldwide. This work aims to treat Methicillin Resistant Staphylococcus Aureus with an emerging formulation strategy. A new strategy was applied through the synthesis of a highly potent film through the combination of boric acid (BA) and cefotaxime (CTX) in polyvinyl alcohol (PVA) or ethyl cellulose (EC) to combat microbial resistance.& nbsp;The antibacterial activity of the developed formulations was studied against methicillin-susceptible Staphylococcus aureus MSSA, (ATCC (R) 25923 (TM)), oxacillin sensitive S. aureus OSSA (ATCC (R) 29213TM) and methicillinresistant S. aureus, MRSA (ATCC (R) 43300 (TM)) by Kirby Bauer disc diffusion tests and minimum inhibitory concentration (MIC) methods. Fractional inhibitory concentration (FIC) indices demonstrate the significant synergistic effect and a 15 fold increase in antibacterial activity against MRSA (ATCC (R) 43300 (TM)) when CTX was delivered from the cross-linked PVA or EC film containing BA. The combinations of CTX with any of the beta-lactamase inhibitors including clavulanate, sulbactam, and tazobactam did not show any antibacterial activity against MRSA. This novel finding suggests that the use of BA in combination with cefotaxime will substantially improve the efficacy of drugs against multi-drug resistant strains.
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页数:9
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