Superantigens

被引：18

作者：

Stow, Nicholas W. ^{[1
,2
]}

Douglas, Richard ^{[1
,2
]}

Tantilipikorn, Pongsakorn ^{[3
]}

Lacroix, Jean Silvain ^{[4
]}

机构：

[1] N Shore Hosp, Dept Otorhinolaryngol Head & Neck Surg, N Shore City 0740, Auckland, New Zealand

[2] Auckland City Hosp, Dept Otorhinolaryngol Head & Neck Surg, Grafton 1010, New Zealand

[3] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Otolaryngol,div Rhinol & Allergy, Bangkok 10700, Thailand

[4] Univ Hosp Geneva, Dept Otorhinolaryngol Head & Neck Surg, CH-1211 Geneva 14, Switzerland

来源：

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA | 2010年 / 43卷 / 03期

关键词：

Superantigen; Enterotoxin; Rhinosinusitis; Rhinitis; Allergy; Staphylococcus aureus; STAPHYLOCOCCUS-AUREUS ENTEROTOXINS; EPSILON-RI+ CELLS; GLUCOCORTICOID-RECEPTOR-BETA; CHRONIC RHINOSINUSITIS; ALLERGIC RHINITIS; NASAL POLYPS; ATOPIC-DERMATITIS; T-CELLS; MICROBIAL SUPERANTIGENS; IMMUNE-RESPONSES;

D O I：

10.1016/j.otc.2010.02.008

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Superantigens (SAgs) are derived from diverse sources, including bacteria, viruses, and human hepatic tissue. SAgs initially cause lymphocyte activation but then result in clonal deletion and anergy, leading to immune tolerance. They can also act as superallergens by stimulating a broad spectrum of mast cells and basophils in patients with allergic conditions. The newly described staphylococcal SAg-like proteins subvert innate immune function by several mechanisms, which are distinct from SAgs' effects on lymphocytes and other acquired immune processes. There is mounting evidence to suggest that SAgs play a role in the pathophysiology of inflammatory airway disease. The pathophysiologic role of SAg-like proteins awaits clarification.

引用

页码：489 / +

页数：15

共 66 条

[31] SUPERANTIGENS - MECHANISM OF T-CELL STIMULATION AND ROLE IN IMMUNE-RESPONSES [J].