Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

被引：3218
|
作者：
Nusse, Roel [1 ]
Clevers, Hans [2 ]
机构：
[1] Stanford Univ, Howard Hughes Med Inst, Dept Dev Biol, Sch Med, Stanford, CA 94305 USA
[2] Univ Med Ctr Utrecht, Hubrecht Inst, Princess Maxima Ctr Pediat Oncol, Uppsalalaan 8, NL-3584 CT Utrecht, Netherlands
来源：
CELL | 2017年 / 169卷 / 06期
关键词：
IN-VITRO EXPANSION; FAMILIAL EXUDATIVE VITREORETINOPATHY; RECEPTOR-RELATED PROTEIN-5; HAIR FOLLICLE DEVELOPMENT; SMALL-MOLECULE INHIBITORS; DOMINANT ROBINOW SYNDROME; POSTNATAL MAMMARY-GLAND; EMBRYONIC STEM-CELLS; BETA-CATENIN; WNT PROTEINS;
D O I：
10.1016/j.cell.2017.05.016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/beta-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.
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页码：985 / 999
页数：15
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