B(C6F5)3-Catalyzed Michael Reactions: Aromatic C-H as Nucleophiles

被引：48
|
作者：
Li, Wu [1 ]
Werner, Thomas [1 ]
机构：
[1] Univ Rostock, Leibniz Inst Catalysis, Albert Einstein Str 29A, D-18059 Rostock, Germany
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 10期
关键词：
CONJUGATE ADDITION; PARALLEL SYNTHESIS; HYDROGENATION; KETONES; HYDROSILATION; CONSTRUCTION; DIHYDROGEN; SILYLATION; MECHANISM; CATALYSTS;
D O I：
10.1021/acs.orglett.7b00720
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Michael reaction is a widely used reaction for the C-C coupling of electron-poor olefins and C(sp(3))-H pronucleophiles. Herein we report the Michael reaction between alkenes and aromatic as well as heteroaromatic compounds as aromatic C(sp(2))-H nucleophiles under mild conditions. The reaction is catalyzed by readily available Lewis acidic B(C6F5)(3) and proceeds with high regioselectivity for a wide substrate scope.
引用
收藏
页码：2568 / 2571
页数：4
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