Effects of hesperetin on the production of inflammatory mediators in IL-1β treated human synovial cells

被引：43

作者：

Choi, Eun Mi ^{[1
]}

Lee, Young Soon ^{[1
]}

机构：

[1] Kyung Hee Univ, Dept Food & Nutr, Seoul 130701, South Korea

来源：

CELLULAR IMMUNOLOGY | 2010年 / 264卷 / 01期

关键词：

Hesperetin; SW982; Matrix metalloproteinases; Cytokines; Mitogen-activated protein kinases; RHEUMATOID-ARTHRITIS; PATHOGENESIS; KINASE;

D O I：

10.1016/j.cellimm.2010.05.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This study was conducted to evaluate the efficacy of hesperetin in regulating interleukin-1 beta (IL-1 beta)-induced production of the matrix metalloproteinase (MMP)-3 and IL-6 in human synovial cell line, SW982. Treatment with hesperetin at 1 or 10 mu M significantly (P < 0.05) inhibited IL-1 beta-induced MMP-3 and IL-6 production when measured by enzyme-linked immunosorbent assay (ELISA). The effects of hesperetin on the activation of mitogen-activated protein kinases (MAPKs) were also examined in SW982 cells by ELISA assay. IL-1 beta-induced JNK activation was inhibited by hesperetin. These results suggest that hesperetin reduces the production of MMP and IL-6 in SW982 synovial cells by inhibiting JNK. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1 / 3

页数：3

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