Prognostic impact of prognostic nutritional index in advanced (stage IIIB/IV) non-small cell lung cancer patients

被引：9
作者：
Li, X. L. [1 ]
Yao, Z. H. [2 ]
Wan, Y. Y. [2 ]
Mou, X. Y. [1 ]
Ni, Y. H. [1 ]
Sun, E. L. [1 ]
Zang, D. [1 ]
Lin, D. J. [2 ]
机构：
[1] Shandong Univ, Shandong Prov Hosp, Dept Healthcare Resp Med, Jinan, Shandong, Peoples R China
[2] Shandong Univ, Shandong Prov Hosp, Dept Resp Med, Jinan, Shandong, Peoples R China
来源：
NEOPLASMA | 2019年 / 66卷 / 06期
关键词：
non-small cell lung cancer; prognostic nutritional index; prognosis; TUMOR-INFILTRATING LYMPHOCYTES; SERUM-ALBUMIN LEVELS; PREDICTIVE-VALUE; OPEN-LABEL; SURVIVAL; RATIO; CHEMOTHERAPY; MORTALITY; OUTCOMES; MARKERS;
D O I：
10.4149/neo_2019_190125N76
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prognostic nutritional index (PNI) is a parameter reflecting prognosis for various cancers, including resected lung cancer. However, there were few reports to study the relationship between the PNI and overall survival (OS) in patients with advanced (stage IIIB/IV) non-small lung cancer (NSCLC). In this study, we collected the clinical data of 315 patients with advanced (stage IIIB/IV) NSCLC who had received chemotherapy or epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) between January 2010 and June 2011. Survival curves were plotted using the Kaplan-Meier method. Multivariate analyses were used to evaluate prognostic significance of PNI in patients with advanced (stage IIIB/IV) NSCLC. In our analysis, we found that PNI (p=0.001) was significantly associated with OS in patients with advanced (stage IIIB/IV) NSCLC, so was smoking (p<0.001) and disease stage (p=0.005). We demonstrated that PNI could be utilized to predict survival outcomes in patients with advanced (stage IIIB/IV) NSCLC. Patients with a lower PNI may have worse prognosis.
引用
收藏
页码：971 / 977
页数：7
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