Natural ligand of mouse CD1d1: Cellular glycosylphosphatidylinositol

被引：350

作者：

Joyce, S ^{[1
]}

Woods, AS

Yewdell, JW

Bennink, JR

De Silva, AD

Boesteanu, A

Balk, SP

Cotter, RJ

Brutkiewicz, RR

机构：

[1] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Microbiol & Immunol, Hershey, PA 17033 USA

[2] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

[4] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA

[5] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol, Boston, MA 02215 USA

来源：

SCIENCE | 1998年 / 279卷 / 5356期

关键词：

D O I：

10.1126/science.279.5356.1541

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mouse CD1d1, a member of the CD1 family of evolutionarily conserved major histocompatibility antigen-like molecules, controls the differentiation and function of a T lymphocyte subset, NK1(+) natural T cells, proposed to regulate immune responses. The CD1d1 crystal structure revealed a large hydrophobic binding site occupied by a ligand of unknown chemical nature. Mass spectrometry and metabolic radiolabeling were used to identify cellular glycosylphosphatidylinositol as a major natural ligand of CD1d1. CD1d1 bound glycosylphosphatidylinositol through its phosphatidylinositol aspect with high affinity. Glycosylphosphatidylinositol or another glycolipid could be a candidate natural ligand for CD1d1-restricted T cells.

引用

页码：1541 / 1544

页数：4

共 27 条

[1] AN NK1.1+ CD4+8- SINGLE-POSITIVE THYMOCYTE SUBPOPULATION THAT EXPRESSES A HIGHLY SKEWED T-CELL ANTIGEN RECEPTOR-V-BETA FAMILY [J].