Curative, Organ-Sparing, Multimodal, Perioperative Treatment of a Young Patient with a Rectoanal Inflammatory Myofibroblastic Tumor

被引：2

作者：

Schoffski, Patrick ^{[1
]}

Vander Borght, Sara ^{[2
,3
]}

Vanden Bempt, Isabelle ^{[3
]}

Jentjens, Sander ^{[4
]}

Vandecaveye, Vincent ^{[5
]}

Sciot, Raf ^{[2
]}

De Hertogh, Gert ^{[2
]}

Christiaens, Melissa ^{[6
]}

Wolthuis, Albert ^{[7
]}

机构：

[1] Univ Hosp Leuven, Dept Gen Med Oncol, Leuven, Belgium

[2] Univ Hosp Leuven, Dept Pathol, Leuven, Belgium

[3] Univ Hosp Leuven, Dept Human Genet, Leuven, Belgium

[4] Univ Hosp Leuven, Dept Nucl Med, Leuven, Belgium

[5] Univ Hosp Leuven, Dept Radiol, Leuven, Belgium

[6] Univ Hosp Leuven, Dept Radiotherapy Oncol, Leuven, Belgium

[7] Univ Hosp Leuven, Dept Abdominal Surg, Leuven, Belgium

来源：

ONCOLOGY RESEARCH AND TREATMENT | 2021年 / 44卷 / 05期

关键词：

Inflammatory myofibroblastic tumor; ALK; Crizotinib; Curative treatment; Multimodality treatment; ALK;

D O I：

10.1159/000515710

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: We report the case of a young female patient with a technically resectable, nonmetastatic, rectoanal, anaplastic lymphoma kinase gene (ALK)-translocated inflammatory myofibroblastic tumor (IMFT). Case Presentation: The patient was successfully treated preoperatively with the tyrosine kinase inhibitor (TKI) crizotinib, to downsize the primary tumor, followed by sphincter-sparing surgery, and adjuvant radiotherapy and crizotinib. She is now in follow-up with good sphincter function and with no evidence of active disease. Conclusion: Pre- and postoperative treatment administration of crizotinib can be given with curative intent to patients with locally advanced, nonmetastatic IMFTs to avoid mutilating surgery.

引用

页码：269 / 275

页数：7

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