PIKKs - the solenoid nest where partners and kinases meet

被引：60
作者：
Baretic, Domagoj [1 ]
Williams, Roger L. [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 0QH, England
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2014年 / 29卷
关键词：
DEPENDENT PROTEIN-KINASE; MESSENGER-RNA DECAY; STRAND BREAK REPAIR; CATALYTIC SUBUNIT; MAMMALIAN TARGET; DNA-DAMAGE; CRYSTAL-STRUCTURE; RAG GTPASES; COMPLEX; MTOR;
D O I：
10.1016/j.sbi.2014.11.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The recent structure of a truncated mTOR in a complex with mLST8 has provided a basic framework for understanding all of the phosphoinositide 3-kinase (PI3K)-related kinases (PIKKs): mTOR, ATM, ATR, SMG-1, TRRAP and DNA-PK. The PIKK kinase domain is encircled by the FAT domain, a helical solenoid that is present in all PIKKs. PIKKs also have an extensive helical solenoid N-terminal to the FAT domain for which there is limited structural information. This N-terminal helical solenoid is essential for binding proteins that associate with the PIKKs to regulate their activity and cellular localization.
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页码：134 / 142
页数：9
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