Study of the CTLA-4 gene polymorphisms in systemic lupus erythematosus (SLE) samples from Malaysia

被引：39

作者：

Chua, Kek-Heng ^{[1
,2
]}

Puah, Suat-Moi

Chew, Ching-Hoong

Tan, Si-Yen ^{[3
]}

Lian, Lay-Hoong

机构：

[1] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Ctr Genom Res, Kuala Lumpur 50603, Malaysia

[3] Univ Malaya, Dept Med, Kuala Lumpur 50603, Malaysia

来源：

ANNALS OF HUMAN BIOLOGY | 2010年 / 37卷 / 02期

关键词：

ASSOCIATION; SUSCEPTIBILITY; JAPANESE; PROMOTER; REGION; RFLP;

D O I：

10.3109/03014460903325185

中图分类号：

Q98 [人类学];

学科分类号：

030303 ;

摘要：

In this study, we investigated the polymorphisms of the exon 1 (+49A/G), promoter sites (-1722T/C, -1661A/G, -318C/T), and 3'-untranslated region (3'-UTR) (+6230 A/G) of the CTLA-4 gene in systemic lupus erythematosus (SLE) affected patients. Polymerase chain reaction-restriction fragment length polymorphism was used to determine genotypes of these five markers in 130 SLE patients and 130 healthy controls. Of the five tested polymorphisms, there was no statistical significant difference between the genotypic and allelic frequencies of patients with SLE and controls. Hence, we propose that the CTLA-4 gene does not play a major role in the genetic susceptibility to the development of SLE in the Malaysian population.

引用

页码：275 / 281

页数：7

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