Advances in Biological Function and Clinical Application of Small Extracellular Vesicle Membrane Proteins

被引：26

作者：

Huang, Defa ^{[1
,2
]}

Chen, Jie ^{[1
,2
]}

Hu, Die ^{[1
,2
]}

Xie, Fangfang ^{[1
,2
]}

Yang, Tong ^{[1
,2
]}

Li, Zhengzhe ^{[1
,2
]}

Wang, Xiaoxing ^{[1
,2
]}

Xiao, Yongwei ^{[1
,2
]}

Zhong, Jianing ^{[3
]}

Jiang, Yu ^{[4
]}

Zhang, Xiaokang ^{[1
,5
]}

Zhong, Tianyu ^{[1
,2
,3
,6
]}

机构：

[1] Gannan Med Univ, Sch Clin Med 1, Ganzhou, Peoples R China

[2] Gannan Med Univ, Affiliated Hosp 1, Lab Med, Ganzhou, Peoples R China

[3] Gannan Med Univ, Minist Educ, Key Lab Prevent & Treatment Cardiovasc & Cerebrov, Ganzhou, Peoples R China

[4] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA

[5] Gannan Med Univ, Dept Prevent Med, Ganzhou, Peoples R China

[6] Gannan Med Univ, Affiliated Hosp 1, Precis Med Ctr, Ganzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

small extracellular vesicles (sEVs); exosomes; membrane protein; biomarker; diagnosis; targeted therapy; BREAST-CANCER; PROMOTE METASTASIS; EXOSOMES; CELLS; GLYPICAN-1; PLASMA; HEAD;

D O I：

10.3389/fonc.2021.675940

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Small extracellular vesicles are membrane-bound vesicles secreted into extracellular spaces by virtually all types of cells. These carry a large number of membrane proteins on their surface that are incorporated during their biogenesis in cells. The composition of the membrane proteins hence bears the signature of the cells from which they originate. Recent studies have suggested that the proteins on these small extracellular vesicles can serve as biomarkers and target proteins for the diagnosis and treatment of diseases. This article classifies small extracellular vesicle membrane proteins and summarizes their pathophysiological functions in the diagnosis and treatment of diseases.

引用

页数：14

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