6-HYDROXY-L-NICOTINE EFFECTS ON ANXIETY AND DEPRESSION IN A RAT MODEL OF CHLORISONDAMINE

被引：0
作者：
Ionita, Radu [1 ]
Valu, Vlad Mihai [1 ]
Postu, Paula Alexandra [1 ]
Cioanca, Oana [2 ]
Hritcu, Lucian [1 ]
Mihasan, Marius [1 ]
机构：
[1] Alexandru Ioan Cuza Univ, Dept Biol, 11 Carol I Blvd, Iasi, Romania
[2] Gr T Popa Univ Med & Pharm, Fac Pharm, Dept Pharmacognosy, 16 Univ St, Iasi, Romania
来源：
FARMACIA | 2017年 / 65卷 / 02期
关键词：
nicotine; 6-hydroxy-l-nicotine; chlorisondamine; anxiety; depression; Alzheimer's disease; BRAIN OXIDATIVE STRESS; ARTHROBACTER-NICOTINOVORANS; ALZHEIMER-DISEASE; NICOTINE;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
6-hydroxy-L-nicotine (6HLN), a nicotine derivative from nicotine degradation by Arthrobacter nicotinovorans pAOl strain, was found to improve behavioural deficits and to reverse oxidative stress in the rat brain. We evaluated the anxiolytic and antidepressant effects of nicotine (0.3 mg/kg b.w.) and 6HLN (0.3 mg/kg b.w.) using a chlorisondamine (CHL) rat model. The anxiolytic effect was evaluated by elevated plus maze test, while the antidepressant effect was investigated using the forced swimming test. Both nicotine and 6HLN improved cognition related behaviours in anxiety and depression, effectively induced by CHL in the laboratory rats.
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收藏
页码：237 / 240
页数：4
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