Asymptomatic and Submicroscopic Carriage of Plasmodium knowlesi Malaria in Household and Community Members of Clinical Cases in Sabah, Malaysia

被引：62
作者：
Fornace, Kimberly M. [1 ]
Nuin, Nor Afizah [3 ]
Betson, Martha [2 ,8 ]
Grigg, Matthew J. [4 ,7 ]
William, Timothy [4 ,5 ,6 ]
Anstey, Nicholas M. [4 ,7 ]
Yeo, Tsin W. [4 ,7 ]
Cox, Jonathan [1 ]
Ying, Lau Tiek [3 ]
Drakeley, Chris J. [1 ]
机构：
[1] London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England
[2] Univ London Royal Vet Coll, London, England
[3] Univ Sabah Malaysia, Biotechnol Res Inst, Kota Kinabalu, Malaysia
[4] Sabah Menzies Sch Hlth Res, Infect Dis Soc, Clin Res Unit, Kota Kinabalu, Malaysia
[5] Clin Res Ctr, Sabah Dept Hlth, Kota Kinabalu, Malaysia
[6] Jesselton Med Ctr, Kota Kinabalu, Malaysia
[7] Menzies Sch Hlth Res, Darwin, NT, Australia
[8] Univ Surrey, Guildford GU2 5XH, Surrey, England
来源：
JOURNAL OF INFECTIOUS DISEASES | 2016年 / 213卷 / 05期
基金：
英国经济与社会研究理事会; 英国医学研究理事会;
关键词：
malaria; Plasmodium knowlesi; submicroscopic infection; asymptomatic parasitemia; REAL-TIME PCR; INFECTIONS; FALCIPARUM; VIETNAM; VIVAX; ASSAY;
D O I：
10.1093/infdis/jiv475
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.
引用
收藏
页码：784 / 787
页数：4
相关论文
共 15 条
  • [1] A Prospective Comparative Study of Knowlesi, Falciparum, and Vivax Malaria in Sabah, Malaysia: High Proportion With Severe Disease From Plasmodium Knowlesi and Plasmodium Vivax But No Mortality With Early Referral and Artesunate Therapy
    Barber, Bridget E.
    William, Timothy
    Grigg, Matthew J.
    Menon, Jayaram
    Auburn, Sarah
    Marfurt, Jutta
    Anstey, Nicholas M.
    Yeo, Tsin W.
    [J]. CLINICAL INFECTIOUS DISEASES, 2013, 56 (03) : 383 - 397
  • [2] Epidemiology of Plasmodium knowlesi malaria in north-east Sabah, Malaysia: family clusters and wide age distribution
    Barber, Bridget E.
    William, Timothy
    Dhararaj, Prabakaran
    Anderios, Fread
    Grigg, Matthew J.
    Yeo, Tsin W.
    Anstey, Nicholas M.
    [J]. MALARIA JOURNAL, 2012, 11
  • [3] A TaqMan real-time PCR assay for the detection and quantitation of Plasmodium knowlesi
    Divis, Paul C. S.
    Shokoples, Sandra E.
    Singh, Balbir
    Yanow, Stephanie K.
    [J]. MALARIA JOURNAL, 2010, 9
  • [4] Factors that are associated with the risk of acquiring Plasmodium knowlesi malaria in Sabah, Malaysia: a case-control study protocol
    Grigg, M. J.
    William, T.
    Drakeley, C. J.
    Jelip, J.
    von Seidlein, L.
    Barber, B. E.
    Fornace, K. M.
    Anstey, N. M.
    Yeo, T. W.
    Cox, J.
    [J]. BMJ OPEN, 2014, 4 (08):
  • [5] Spurious Amplification of a Plasmodium vivax Small-Subunit RNA Gene by Use of Primers Currently Used To Detect P. knowlesi
    Imwong, Mallika
    Tanomsing, Naowarat
    Pukrittayakamee, Sasithon
    Day, Nicholas P. J.
    White, Nicholas J.
    Snounou, Georges
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (12) : 4173 - 4175
  • [6] Detection of Plasmodium knowlesi DNA in the urine and faeces of a Japanese macaque (Macaca fuscata) over the course of an experimentally induced infection
    Kawai, Satoru
    Sato, Megumi
    Kato-Hayashi, Naoko
    Kishi, Hisashi
    Huffman, Michael A.
    Maeno, Yoshimasa
    Culleton, Richard
    Nakazawa, Shusuke
    [J]. MALARIA JOURNAL, 2014, 13
  • [7] Co-infections of Plasmodium knowlesi, P. falciparum, and P. vivax among Humans and Anopheles dirus Mosquitoes, Southern Vietnam
    Marchand, Ron P.
    Culleton, Richard
    Maeno, Yoshimasa
    Nguyen Tuyen Quang
    Nakazawa, Shusuke
    [J]. EMERGING INFECTIOUS DISEASES, 2011, 17 (07) : 1232 - 1239
  • [8] Factors determining the occurrence of submicroscopic malaria infections and their relevance for control
    Okell, Lucy C.
    Bousema, Teun
    Griffin, Jamie T.
    Ouedraogo, Andre Lin
    Ghani, Azra C.
    Drakeley, Chris J.
    [J]. NATURE COMMUNICATIONS, 2012, 3
  • [9] Submicroscopic Infection in Plasmodium falciparum-Endemic Populations: A Systematic Review and Meta-Analysis
    Okell, Lucy C.
    Ghani, Azra C.
    Lyons, Emily
    Drakeley, Chris J.
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2009, 200 (10) : 1509 - 1517
  • [10] Multiplex 5′ Nuclease Quantitative Real-Time PCR for Clinical Diagnosis of Malaria and Species-Level Identification and Epidemiologic Evaluation of Malaria-Causing Parasites, Including Plasmodium knowlesi
    Reller, Megan E.
    Chen, Wan Hsin
    Dalton, Justin
    Lichay, Marguerite A.
    Dumler, J. Stephen
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2013, 51 (09) : 2931 - 2938
12