Asymptomatic and Submicroscopic Carriage of Plasmodium knowlesi Malaria in Household and Community Members of Clinical Cases in Sabah, Malaysia

被引：62

作者：

Fornace, Kimberly M. ^{[1
]}

Nuin, Nor Afizah ^{[3
]}

Betson, Martha ^{[2
,8
]}

Grigg, Matthew J. ^{[4
,7
]}

William, Timothy ^{[4
,5
,6
]}

Anstey, Nicholas M. ^{[4
,7
]}

Yeo, Tsin W. ^{[4
,7
]}

Cox, Jonathan ^{[1
]}

Ying, Lau Tiek ^{[3
]}

Drakeley, Chris J. ^{[1
]}

机构：

[1] London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England

[2] Univ London Royal Vet Coll, London, England

[3] Univ Sabah Malaysia, Biotechnol Res Inst, Kota Kinabalu, Malaysia

[4] Sabah Menzies Sch Hlth Res, Infect Dis Soc, Clin Res Unit, Kota Kinabalu, Malaysia

[5] Clin Res Ctr, Sabah Dept Hlth, Kota Kinabalu, Malaysia

[6] Jesselton Med Ctr, Kota Kinabalu, Malaysia

[7] Menzies Sch Hlth Res, Darwin, NT, Australia

[8] Univ Surrey, Guildford GU2 5XH, Surrey, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 213卷 / 05期

基金：

英国医学研究理事会; 英国经济与社会研究理事会;

关键词：

malaria; Plasmodium knowlesi; submicroscopic infection; asymptomatic parasitemia; REAL-TIME PCR; INFECTIONS; FALCIPARUM; VIETNAM; VIVAX; ASSAY;

D O I：

10.1093/infdis/jiv475

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

引用

页码：784 / 787

页数：4

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