Therapeutic Effects of Probiotic Minas Frescal Cheese on the Attenuation of Ulcerative Colitis in a Murine Model

被引:37
|
作者
Cordeiro, Barbara F. [1 ]
Alves, Juliana L. [1 ]
Belo, Giovanna A. [1 ]
Oliveira, Emiliano R. [1 ]
Braga, Marina P. [1 ]
da Silva, Sara H. [1 ]
Lemos, Luisa [1 ,2 ]
Guimaraes, Jonas T. [3 ]
Silva, Ramon [3 ,4 ]
Rocha, Ramon S. [3 ,4 ]
Jan, Gwenael [5 ]
Le Loir, Yves [5 ]
Silva, Marcia Cristina [4 ]
Freitas, Monica Q. [3 ]
Esmerino, Erick A. [3 ]
Gala-Garcia, Alfonso [1 ]
Ferreira, Enio [1 ]
Faria, Ana Maria C. [1 ]
Cruz, Adriano G. [4 ]
Azevedo, Vasco [1 ]
do Carmo, Fillipe L. R. [1 ,5 ]
机构
[1] Univ Fed Minas Gerais UFMG, Inst Ciencias Biol, Belo Horizonte, MG, Brazil
[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Infect Dis, Boston, MA 02115 USA
[3] Univ Fed Fluminense UFF, Fac Med Vet, Niteroi, RJ, Brazil
[4] Inst Fed Educ Ciencia & Tecnol Rio de Janeiro IFR, Dept Alimentos, Rio De Janeiro, Brazil
[5] Agrocampus Ouest, Inst Agro, STLO, INRAE, Rennes, France
来源
FRONTIERS IN MICROBIOLOGY | 2021年 / 12卷
关键词
functional food; probiotic; colitis; cheese; Lactococcus lactis; inflammatory bowel disease;
D O I
10.3389/fmicb.2021.623920
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Inflammatory bowel diseases (IBDs) constitute disturbances of gastrointestinal tract that cause irreversible changes in the structure and function of tissues. Ulcerative colitis (UC), the most frequent IBD in the population, is characterized by prominent inflammation of the human colon. Functional foods containing probiotic bacteria have been studied as adjuvants to the treatment or prevention of IBDs. The selected probiotic strain Lactococcus lactis NCDO 2118 (L. lactis NCDO 2118) exhibits immunomodulatory effects, with promising results in UC mouse model induced by dextran sodium sulfate (DSS). Additionally, cheese is a dairy food that presents high nutritional value, besides being a good delivery system that can be used to improve survival and enhance the therapeutic effects of probiotic bacteria in the host. Therefore, this work investigated the probiotic therapeutic effects of an experimental Minas Frescal cheese containing L. lactis NCDO 2118 in DSS-induced colitis in mice. During colitis induction, mice that consumed the probiotic cheese exhibited reduced in the severity of colitis, with attenuated weight loss, lower disease activity index, limited shortening of the colon length, and reduced histopathological score. Moreover, probiotic cheese administration increased gene expression of tight junctions' proteins zo-1, zo-2, ocln, and cln-1 in the colon and increase IL-10 release in the spleen and lymph nodes. In this way, this work demonstrates that consumption of probiotic Minas Frescal cheese, containing L. lactis NCDO 2118, prevents the inflammatory process during DSS-induced colitis in mice, opening perspectives for the development of new probiotic functional foods for personalized nutrition in the context of IBD.
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页数:16
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