Synthesis of New 4-Methyl-2-(4-pyridyl)-1,2,3,4-tetrahydroquinolines as Potent Antifungal Compounds

被引：9

作者：

Vargas Mendez, Leonor Y. ^{[2
]}

Zacchino, Susana A. ^{[3
]}

Kouznetsov, Vladimir V. ^{[1
]}

机构：

[1] Univ Ind Santander, Lab Quim Organ & Biomol, Bucaramanga 678, Colombia

[2] Univ Santo Tomas, Grp Invest Ambientales, Bucaramanga 1076, Colombia

[3] Univ Nacl Rosario, Lab Farmacognosia, RA-2000 Rosario, Santa Fe, Argentina

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2010年 / 21卷 / 01期

关键词：

homoallylamines; 2-(4-pyridyl)-1,2,3,4-tetrahydroquinolines; antifungal activity; INVASIVE ASPERGILLOSIS; HETEROCYCLIC SYNTHESIS; BUILDING-BLOCKS; 4-N-ARYL(BENZYL)AMINO-4-HETARYL-1-BUTENES; CELL;

D O I：

10.1590/S0103-50532010000100016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis, spectral characterization and biological results of new series of 2-(4-pyridyl)-1,2,3,4-tetrahydroquinolines and their closer precursors, -N-aryl-N-[1-(4-pyridyl)but-3-enyl]amines are reported. It was found that both g-pyridyl substituted precursors and final products, tetrahydroquinolines, showed very good antifungal activities against Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Microsporum gypseun, Trichophyton rubrum and Trichophyton mentagrophytes.

引用

页码：105 / U56

页数：15

共 15 条

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