Fe3O4 loaded single wall carbon nanotubes and 1-methyl-3-octylimidazlium chloride as two amplifiers for fabrication of highly sensitive voltammetric sensor for epirubicin anticancer drug analysis

A novel anticancer drug sensor was proposed for the making of an electrochemical tool consisting of both conducting 3D Fe3O4 decorated single wall carbon nanotubes (Fe3O4-SWCNTs) nanocomposite and 1-methyl-3-octylimidazlium chloride (MOCTICI) into carbon paste electrode (CPE) for epirubicin determination. In the first step, the structure and morphology of 3D Fe3O4-SWCNTs nano-composites were characterized with XRD and SEM methods in the first step. As a result of the high electrical conductivity of Fe3O4-SWCNTs and MOCTICI, the Fe3O4-SWCNTs/MOCTICl/CPE showed significant improvement on the oxidation signal of epirubicin and was used for the determination of epirubicin in a concentration range of 0.02-700 mu M with a detection limit of 7.0 nM. The Fe3O4-SWCNTs/MOCTICl/CPE was successfully suggested for the detection of epirubicin in injection and pharmaceutical serum samples. (C) 2018 Elsevier B.V. All rights reserved.