Asymmetric sulfa-Michael additions

被引：291
作者：
Enders, Dieter [1 ]
Luettgen, Karsten [1 ]
Narine, Arun A. [1 ]
机构：
[1] Univ Aachen, Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
来源：
SYNTHESIS-STUTTGART | 2007年 / 07期
关键词：
sulfur compounds; asymmetric Michael additions; alpha; beta-unsaturated carbonyl compounds; tandem reactions; organocatalysis;
D O I：
10.1055/s-2007-965968
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Numerous asymmetric methods have been developed over the past 30 years to effect the Michael reaction of sulfur donors and Michael acceptors. Many of these stoichiometric and catalytic methods are complementary to one another, each having a certain range of substrate tolerance. Organocatalysis has a place at the origin of this field in the discovery of cinchona alkaloid catalyzed sulfa-Michael reactions. At the same time, it is involved in the current state-of-the-art as several elegant tandem processes that employ secondary amine catalysts and involve initial sulfa-Michael additions have been developed.
引用
收藏
页码：959 / 980
页数：22
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