Contemporary theory of enantioseparations in capillary electrophoresis

被引：91
作者：
Chankvetadze, Bezhan [1 ]
机构：
[1] Tbilisi State Univ, Inst Phys & Analyt Chem, Sch Exact & Nat Sci, Chavchavadze Ave 1, Tbilisi 0179, Georgia
来源：
JOURNAL OF CHROMATOGRAPHY A | 2018年 / 1567卷
基金：
美国国家科学基金会;
关键词：
Capillary electrophoresis; Theory; Enantioseparations; Chiral separation mechanisms in CE; Cyclodextrins; NUCLEAR-MAGNETIC-RESONANCE; SELECTOR-SELECTAND INTERACTIONS; COMPLEX-FORMATION EQUILIBRIA; ENANTIOMER MIGRATION ORDER; NATIVE BETA-CYCLODEXTRIN; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; RESOLUTION COMPUTER-SIMULATION; HOST-GUEST COMPLEXATION; AMINO-ACID-SEQUENCE; CHIRAL SEPARATION;
D O I：
10.1016/j.chroma.2018.07.041
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The first separation of enantiomers in capillary electrophoresis (CE) counts slightly longer than three decades. Fast development of the practice and theory of chiral CE occurred in the past 30 years and today one can consider this technology to have a solid and mature theoretical background. The goal of the present review is not only to summarize the history and contemporary theory of enantioseparations by using CE but also to present the authors personal view where shall we head to with this attractive technology not only from the viewpoint of separation of enantiomers but also for better understanding the mechanisms of non-covalent (enantioselective) interactions in chemistry, biology, medicine and related disciplines. (C) 2018 Elsevier B.V. All rights reserved.
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页码：2 / 25
页数：24
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