The concept of differential subordination was introduced in [3] by S.S. Miller and P.T. Mocanu and the concept of strong differential subordination was introduced in [1], [2] by J.A. Antonin and S. Romaguera. In [5] we have studied the strong differential subordinations in the general case and in [6] we have studied the first order linear strong differential subordinations. In this paper we study the second order linear strong differential subordinations. Our results may be applied to deduce sufficient conditions for univalence in the unit disc, such as starlikeness, convexity, alpha-convexity, close-to-convexity respectively.