Biotechnological challenges of phage therapy

被引：151

作者：

Skurnik, Mikael ^{[1
]}

Pajunen, Maria

Kiljunen, Saija

机构：

[1] Univ Helsinki, Dept Bacteriol & Immunol, Haartman Inst, POB 21, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Inst Biotechnol, FIN-00014 Helsinki, Finland

[3] Helsinki Univ Hosp Lab, Helsinki, Finland

[4] Univ Turku, Dept Virol, Helsinki, Finland

来源：

BIOTECHNOLOGY LETTERS | 2007年 / 29卷 / 07期

关键词：

bacteriophage; therapy; sequence; gene; toxin; virulence factor;

D O I：

10.1007/s10529-007-9346-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The challenges for successful launching of a profitable phage therapeutic product include intellectual property rights, safety issues, reproducibility, stability and robustness of the product. A successful and marketable product would be a highly purified bacteriophage preparation containing one or several fully characterized phages, accompanied by optimized methods of administration and backed up by properly controlled efficacy and safety studies.

引用

页码：995 / 1003

页数：9

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