Misconstrued versatility of Ganoderma lucidum: a key player in multi-targeted cellular signaling

被引：30
作者：
Gill, Balraj Singh [1 ]
Sharma, Prateek [1 ]
Kumar, Raj [2 ]
Kumar, Sanjeev [1 ,2 ]
机构：
[1] Cent Univ Punjab, Ctr Biosci, Bathinda 151001, India
[2] Cent Univ Punjab, Ctr Chem & Pharmaceut Sci, Sch Basic & Appl Sci, Bathinda 151001, India
来源：
TUMOR BIOLOGY | 2016年 / 37卷 / 03期
关键词：
Ganoderma lucidum; Terpenoids; Polysaccharides; Ganoderic acid (GA); Cancer; INHIBITS TUMOR INVASION; FRUITING BODIES; CANCER CELLS; IMMUNOMODULATORY PROTEIN; ANTIOXIDANT ACTIVITY; IN-VITRO; ANTIHERPETIC ACTIVITIES; LANOSTANOID TRITERPENE; DIABETIC-NEPHROPATHY; ANTITUMOR ACTIVITIES;
D O I：
10.1007/s13277-015-4709-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A Basidiomycetes fungus belonging to polypore family of mushrooms, Ganoderma lucidum (GL), has been known since a long time for their myriad therapeutic indications. Renowned as an invaluable resource of cardinal mycoconstituents they encompass numerous terpenoids polysaccharides and proteins. Possessing the therapeutically potent lanosteroidal skeleton, terpenoids are upheld for their invariable participation in therapeutically diverse bioactivities. Polysaccharides and proteins exhibiting distinguishable bioactivities provide this oriental mushroom with additional edges over immune function and anti-cancer potential. This review is a concerted effort to throw light upon the therapeutic versatility of the fungus, shadowed by various other natural products. An effort has been made towards conglomerating the mycoconstituents decisive for the many activities portrayed by this fungus. More importantly, this review seeks to fathom the inextricable role played by derivatives in modulating signaling cascades such as downregulation of various mitogenic pathways, inhibiting growth factors, or upregulating certain pathways enhancing cellular integrity.
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页码：2789 / 2804
页数：16
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