Epileptogenesis

被引：229

作者：

Pitkanen, Asla ^{[1
,2
]}

Lukasiuk, Katarzyna ^{[3
]}

Dudek, F. Edward ^{[4
]}

Staley, Kevin J. ^{[5
]}

机构：

[1] Univ Eastern Finland, AI Virtanen Inst Mol Sci, Dept Neurobiol, FI-70211 Kuopio, Finland

[2] Kuopio Univ Hosp, Dept Neurol, FI-70211 Kuopio, Finland

[3] Polish Acad Sci, M Nencki Inst Expt Biol, PL-02093 Warsaw, Poland

[4] Univ Utah, Dept Neurosurg, Sch Med, Salt Lake City, UT 84108 USA

[5] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2015年 / 5卷 / 10期

基金：

芬兰科学院; 美国国家卫生研究院;

关键词：

TEMPORAL-LOBE EPILEPSY; TRAUMATIC BRAIN-INJURY; DENTATE GRANULE CELLS; SPONTANEOUS RECURRENT SEIZURES; CONTROLLED CORTICAL IMPACT; INDUCED STATUS EPILEPTICUS; FLUID PERCUSSION INJURY; MIDDLE CEREBRAL-ARTERY; SPRAGUE-DAWLEY RATS; TERM VIDEO-EEG;

D O I：

10.1101/cshperspect.a022822

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors, and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a treatment indication, and there are no therapies available in clinic to treat individuals at risk of epileptogenesis. However, thanks to active research, a large number of animal models have become available for search of molecular mechanisms of epileptogenesis. The first glimpses of treatment targets and biomarkers that could be developed to become useful in clinic are in sight. However, the heterogeneity of the epilepsy condition, and the dynamics of molecular changes over the course of epileptogenesis remain as challenges to overcome.

引用

页数：17

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