Recognition and stabilization of peptide α-helices using templatable nanoparticle receptors

被引：74
|
作者：
Verma, A [1 ]
Nakade, H [1 ]
Simard, JM [1 ]
Rotello, VM [1 ]
机构：
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 35期
关键词：
D O I：
10.1021/ja047719h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
α-Helices are important structural elements in proteins. To provide a scaffold for the facial recognition of peptides, we have explored the interaction of cationic mixed monolayer protected clusters (MMPCs) with a tetra-aspartate peptide in water. In these studies, substantial enhancement of peptide helicity was observed upon addition of the MMPC. Significantly, this stabilization increased with time, demonstrating templation of the monolayer to the peptide helix. Copyright © 2003 American Chemical Society.
引用
收藏
页码：10806 / 10807
页数：2
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