Bisphosphonates: Pharmacokinetics, bioavailability, mechanisms of action, clinical applications in children, and effects on tooth development

被引：53

作者：

Soares, Ana Prates ^{[1
]}

do Espirito Santo, Renan Fernandes ^{[2
]}

Peres Line, Sergio Roberto ^{[3
]}

Farias Pinto, Maria das Gracas ^{[4
]}

Santos, Pablo de Moura ^{[5
]}

Pereira Toralles, Maria Betania ^{[6
]}

do Espirito Santo, Alexandre Ribeiro ^{[6
]}

机构：

[1] Fed Univ Bahia UFBA, Multidisciplinary Inst Hlth, Rua Rio de Contas 58,Quadra 17,Lote 58, BR-45029094 Vitoria Da Conquista, BA, Brazil

[2] Fed Univ Bahia UFBA, Fac Pharm, Rua Barao de Jeremoabo S-N,Campus Univ Ondina, BR-40170115 Salvador, BA, Brazil

[3] Univ Campinas UNICAMP, Piracicaba Dent Sch, Ave Limeira 901, BR-13414903 Piracicaba, SP, Brazil

[4] Fed Univ Bahia UFBA, Sch Vet Med & Zootechny, Ave Ademar de Barros 500, BR-40170110 Salvador, BA, Brazil

[5] Fed Univ Bahia UFBA, Prof Edgard Santos Univ Hosp, Rua Augusto Viana S-N, BR-40110060 Salvador, BA, Brazil

[6] Fed Univ Bahia UFBA, Inst Hlth Sci, Ave Reitor Miguel Calmon S-N, BR-40110902 Salvador, BA, Brazil

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2016年 / 42卷

关键词：

Bisphosphonates; Tooth; Odontogenesis; Dentin; Dental enamel; NITROGEN-CONTAINING BISPHOSPHONATES; SEVERE OSTEOGENESIS IMPERFECTA; GTP-BINDING PROTEINS; RAT INCISORS; 1-HYDROXYETHYLIDENE-1,1-BISPHOSPHONATE HEBP; 1-BISPHOSPHONATE HEBP; ZOLEDRONIC ACID; SECRETORY AMELOBLASTS; ENAMEL HYPOPLASIA; BONE-RESORPTION;

D O I：

10.1016/j.etap.2016.01.015

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Bisphosphonates (BPs) avidly bind to calcium crystals and inhibit osteoclastic bone resorption, making them useful for treatment of skeletal disorders such as osteoporosis, Paget's disease, osteogenesis imperfecta and metastatic bone diseases. BPs therapeutically act by causing toxic effects on osteoclasts or interfering with specific intracellular pathways in those cells. BPs that possess nitrogen in their composition are called nitrogen-containing BPs (NBPs) and include alendronate, pamidronate, risedronate, ibandronate, and zoledronate. Simple BPs or non-NBPs do not have nitrogen in their composition, include etiodronate and clodronate, and were the first to be tested in animals and clinically used. Because BPs may be administered to pregnant women or children during deciduous and permanent teeth development, it is expected that they might disturb tooth eruption and development. A review of current literature on pharmacokinetics, bioavailability, mechanisms of action, and clinical applications of BPs in children, and their effects on tooth eruption and development is presented. (C) 2016 Published by Elsevier B.V.

引用

页码：212 / 217

页数：6

共 73 条

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