A redundant oncogenic potential of the retinoic receptor (RAR) α, β and γ isoforms in acute promyelocytic leukemia

被引：25
|
作者：
Marinelli, A. [1 ]
Bossi, D. [1 ]
Pelicci, P. G. [1 ]
Minucci, S. [1 ]
机构：
[1] European Inst Oncol, Dept Expt Oncol, I-20100 Milan, Italy
来源：
LEUKEMIA | 2007年 / 21卷 / 04期
关键词：
acute myeloid leukemias; acute promyelocytic leukemia; PML-RAR; retinoic acid;
D O I：
10.1038/sj.leu.2404572
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Alterations of the retinoic acid receptor (RAR) a locus are found in 100% of acute promyelocytic leukemia patients, where chromosomal translocations generate the promyelocytic leukemia (PML)-RAR alpha chimeric protein. Here, we have investigated the biological properties of the other RAR isoforms (RAR beta and RAR gamma), through the generation and characterization of artificial PML-RAR'x' fusion proteins. Surprisingly, we found that all of the RAR isoforms share an identical oncogenic potential in vitro, thus implying that the selection of the RAR alpha locus in leukemia patients must occur - rather than through functional differences among the various RAR isoforms - as the consequence of the nuclear architecture of the different RAR loci.
引用
收藏
页码：647 / 650
页数：4
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