Is There Variation in Crossover Interference Levels Among Chromosomes From Human Males?

被引：5
作者：
Housworth, E. A. [1 ,2 ,3 ]
Stahl, F. W. [4 ]
机构：
[1] Indiana Univ, Dept Math, Bloomington, IN 47405 USA
[2] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA
[3] Indiana Univ, Dept Stat, Bloomington, IN 47405 USA
[4] Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA
来源：
GENETICS | 2009年 / 183卷 / 01期
关键词：
SACCHAROMYCES-CEREVISIAE; MEIOTIC RECOMBINATION; MISMATCH REPAIR; MLH1; MAP;
D O I：
10.1534/genetics.109.103853
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We demonstrate that recent data from human males are consistent with constant interference levels among chromosomes under the two-pathway model, whereas inappropriately fitting shape parameters of Gamma distributions to immunofluorescent interfoci distances observed on finite chromosomes generates false interpretations of higher levels of interference on shorter chromosomes. We provide appropriate statistical methodology.
引用
收藏
页码：403 / 405
页数：3
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