The pro- and anti-tumor role of ILC2s

被引：23
作者：
Trabanelli, Sara [1 ]
Chevalier, Mathieu F. [2 ,3 ,4 ]
Derre, Laurent [2 ]
Jandus, Camilla [1 ]
机构：
[1] Univ Lausanne, UNIL CHUV, Dept Oncol, CH-1066 Epalinges, Switzerland
[2] Univ Hosp Lausanne CHUV, Urol Res Unit, CH-1011 Lausanne, Switzerland
[3] Hop St Louis, Lab Human Immunol Pathophysiol & Immunotherapy, INSERM U976, Paris, France
[4] Univ Paris, Hop St Louis, Inst Rech St Louis, Paris, France
来源：
SEMINARS IN IMMUNOLOGY | 2019年 / 41卷
基金：
瑞士国家科学基金会;
关键词：
Group-2 innate lymphoid cells; ILC2; Cancer; Tumor immunoregulation; INNATE LYMPHOID-CELLS; TRANSCRIPTION FACTOR BCL11B; T-CELLS; TYPE-2; IMMUNITY; FACTOR GATA3; INFLAMMATION; EXPRESSION; GROWTH; IL-33; CARCINOGENESIS;
D O I：
10.1016/j.smim.2019.04.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Group 2 innate lymphoid cells (ILC2s) are critical for the initiation of type 2 inflammatory diseases. However, ILC2s are also involved in the establishment of the immune microenvironment during tumor development, growth and metastasization. In this context, ILC2s have been shown to be either tumor-suppressive or tumor-promoting according to the tumor type, the cytokine secreted and the other immune cells that are, in turn, recruited and/or activated.
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页数：6
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