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Differences in cannabis-related experiences between patients with a first episode of psychosis and controls
被引:27
作者:
Bianconi, F.
[1
]
Bonomo, M.
[1
]
Marconi, A.
[2
]
Kolliakou, A.
[3
]
Stilo, S. A.
[1
]
Iyegbe, C.
[1
]
Gurillo Munoz, P.
[4
]
Homayoun, S.
[1
]
Mondelli, V.
[1
]
Luzi, S.
[1
]
Dazzan, P.
[1
]
Prata, D.
[5
,6
]
La Cascia, C.
[7
]
O'Connor, J.
[1
]
David, A.
[1
]
Morgan, C.
[1
]
Murray, R. M.
[1
]
Lynskey, M.
[8
]
Di Forti, M.
[1
]
机构:
[1] Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London WC2R 2LS, England
[2] Univ Roma La Sapienza, Dept Paediat & Child & Adolescent Neuropsychiat, Piazzale Aldo Moro 5, I-00185 Rome, Italy
[3] Kings Coll London, Biomed Res Ctr Nucleus, London WC2R 2LS, England
[4] Hosp Marina Baixa, Alicante, Spain
[5] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neuroimaging, London WC2R 2LS, England
[6] Univ Lisbon, Fac Med, Inst Mol Med, P-1699 Lisbon, Portugal
[7] Univ Palermo, Dept Expt Biomed & Clin Neurosci, Palermo, Italy
[8] Kings Coll London, Addict Dept, Inst Psychiat Psychol & Neurosci, London WC2R 2LS, England
基金:
美国国家卫生研究院;
关键词:
Cannabis;
Cannabis Experience Questionnaire;
experiences;
first episode of psychosis;
psychosis;
HIGH-POTENCY CANNABIS;
POPULATION-BASED SAMPLE;
1ST-EPISODE PSYCHOSIS;
SUBSTANCE USE;
DEPENDENCE;
ABUSE;
ASSOCIATION;
DISORDERS;
RISK;
SCHIZOPHRENIA;
D O I:
10.1017/S0033291715002494
中图分类号:
B849 [应用心理学];
学科分类号:
040203 ;
摘要:
Background Many studies have reported that cannabis use increases the risk of a first episode of psychosis (FEP). However, only a few studies have investigated the nature of cannabis-related experiences in FEP patients, and none has examined whether these experiences are similar in FEP and general populations. The aim of this study was to explore differences in self-reported cannabis experiences between FEP and non-psychotic populations. Method A total of 252 subjects, who met International Classification of Diseases (ICD)-10 criteria for FEP, and 217 controls who reported cannabis use were selected from the Genetics and Psychosis (GAP) study. The Medical Research Council Social Schedule and the Cannabis Experience Questionnaire were used to collect sociodemographic data and cannabis use information, respectively. Results Both bad' and enjoyable' experiences were more commonly reported by FEP subjects than controls. Principal components factor analysis identified four components which explained 62.3% of the variance. Linear regression analysis on the whole sample showed that the type of cannabis used and beliefs about the effect of cannabis on health all contributed to determining the intensity and frequency of experiences. Linear regression analysis on FEP subjects showed that the duration of cannabis use and amount of money spent on cannabis were strongly related to the intensity and frequency of enjoyable experiences in this population. Conclusions These results suggest a higher sensitivity to cannabis effects among people who have suffered their first psychotic episode; this hypersensitivity results in them reporting both more bad' and enjoyable' experiences. The greater enjoyment experienced may provide an explanation of why FEP patients are more likely to use cannabis and to continue to use it despite experiencing an exacerbation of their psychotic symptoms.
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页码:995 / 1003
页数:9
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