Multi-Megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second

被引：385
作者：
Wieser, Wolfgang [1 ]
Biedermann, Benjamin R. [1 ]
Klein, Thomas [1 ]
Eigenwillig, Christoph M. [1 ]
Huber, Robert [1 ]
机构：
[1] Univ Munich, Fak Phys, Lehrstuhl BioMol Opt, D-80538 Munich, Germany
来源：
OPTICS EXPRESS | 2010年 / 18卷 / 14期
关键词：
OPTICAL COHERENCE TOMOGRAPHY; DOMAIN MODE-LOCKING; WAVELENGTH-SWEPT LASER; HIGH-SPEED; LOCKED LASER; HUMAN RETINA; AXIAL SCANS; MICROSCOPY; REFLECTOMETRY; ACQUISITION;
D O I：
10.1364/OE.18.014685
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We present ultra high speed optical coherence tomography (OCT) with multi-megahertz line rates and investigate the achievable image quality. The presented system is a swept source OCT setup using a Fourier domain mode locked (FDML) laser. Three different FDML-based swept laser sources with sweep rates of 1, 2.6 and 5.2MHz are compared. Imaging with 4 spots in parallel quadruples the effective speed, enabling depth scan rates as high as 20.8 million lines per second. Each setup provides at least 98dB sensitivity and similar to 10 mu m resolution in tissue. High quality 2D and 3D imaging of biological samples is demonstrated at full scan speed. A discussion about how to best specify OCT imaging speed is included. The connection between voxel rate, line rate, frame rate and hardware performance of the OCT setup such as sample rate, analog bandwidth, coherence length, acquisition dead-time and scanner duty cycle is provided. Finally, suitable averaging protocols to further increase image quality are discussed. (C) 2010 Optical Society of America
引用
收藏
页码：14685 / 14704
页数：20
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