Purinergic signaling: a novel mechanism in immune surveillance

被引：11

作者：

Mei, Lin ^{[1
]}

Du, Wei ^{[1
]}

Gao, Wei ^{[1
]}

Mei, Qi-bing ^{[2
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Dept Cardiol, Hosp 3, Beijing 100191, Peoples R China

[2] Fourth Mil Med Univ, Sch Pharm, Dept Pharmacol, Xian 710032, Peoples R China

来源：

ACTA PHARMACOLOGICA SINICA | 2010年 / 31卷 / 09期

基金：

中国国家自然科学基金;

关键词：

nucleotides; purinergic receptor; immune surveillance; inflammation; chemotaxis; P2X(7) RECEPTORS; EXTRACELLULAR NUCLEOTIDES; ATP RELEASE; NEUTROPHIL CHEMOTAXIS; IN-VIVO; CELLS; ACTIVATION; CANCER; INJURY; INFLAMMATION;

D O I：

10.1038/aps.2010.128

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Purinergic receptors and the associated signaling cascades are known to play critical roles in cardiovascular, nervous, respiratory, gastrointestinal and urinogenital systems. Recent studies have also shed light on the importance of nucleotides and purinergic receptors in the regulation of the immune response. With a better understanding of the distribution and the receptor subtypes, the purinoceptors have the potential to become important therapeutic targets in inflammation, chemotaxis and immune-related diseases.

引用

页码：1149 / 1153

页数：5

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