Bio-mediated oxidative resolution of racemic 2-substituted 1,2,3,4-tetrahydroquinolines

被引：10

作者：

Qin, Lei ^{[1
]}

Zheng, Daijun ^{[1
]}

Cui, Baodong ^{[1
]}

Wan, Nanwei ^{[1
]}

Zhou, Xiaojian ^{[1
]}

Chen, Yongzheng ^{[1
]}

机构：

[1] Zunyi Med Univ, Sch Pharm, Zunyi 563000, Peoples R China

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 22期

基金：

中国国家自然科学基金;

关键词：

Biocatalysis; Whole cell; Pseudomonas monteilii; Oxidative resolution; 2-Substituted 1,2,3,4-tetrahydroquinolines; DYNAMIC KINETIC RESOLUTION; HIGHLY ENANTIOSELECTIVE HYDROGENATION; CHIRAL TETRAHYDROQUINOLIN-4-OL; AMINE OXIDASE; QUINOLINES; ALCOHOLS; ALKYLATION; CATALYSTS; LIGANDS; SCOPE;

D O I：

10.1016/j.tetlet.2016.04.066

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Whole cell of Pseudomonas monteilii ZMU-T01 strains mediated oxidative resolution of racemic 2-substituted 1,2,3,4-tetrahydroquinolines has been successfully described. A series of highly enantioselective 2 substituted 1,2,3,4-tetrahydroquinoline derivatives were obtained in up to 50% conversion and >99% ee. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：2403 / 2405

页数：3

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