Dendritic Cell Apoptosis: Regulation of Tolerance versus Immunity

被引：91
作者：
Kushwah, Rahul
Hu, Jim [1 ]
机构：
[1] Univ Toronto, Hosp Sick Children, Physiol & Expt Med Res Program, Toronto, ON M5G 1X8, Canada
来源：
JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 02期
基金：
加拿大健康研究院;
关键词：
II-MEDIATED APOPTOSIS; TUMOR-NECROSIS-FACTOR; T-CELLS; IN-VIVO; CANCER-IMMUNOTHERAPY; BREAST-CANCER; FAMILY-MEMBER; ACTIVATION; INDUCTION; DEATH;
D O I：
10.4049/jimmunol.1000325
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dendritic cell (DC) apoptosis is an important event that regulates the balance between tolerance and immunity through multiple pathways, and defects in DC apoptosis can trigger autoimmunity. DC apoptosis is also associated with immunosuppression and has been observed under several pathologies and infections. Recent studies indicate that apoptotic DCs can also play an active role in induction of tolerance. This review discusses the regulatory pathways of DC apoptosis, stimuli inducing DC apoptosis, and the implications of DC apoptosis in the induction of immunosuppression and/or tolerance. The Journal of Immunology, 2010, 185: 795-802.
引用
收藏
页码：795 / 802
页数：8
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