Dendritic Cell Apoptosis: Regulation of Tolerance versus Immunity

被引：91
作者：
Kushwah, Rahul
Hu, Jim [1 ]
机构：
[1] Univ Toronto, Hosp Sick Children, Physiol & Expt Med Res Program, Toronto, ON M5G 1X8, Canada
来源：
JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 02期
基金：
加拿大健康研究院;
关键词：
II-MEDIATED APOPTOSIS; TUMOR-NECROSIS-FACTOR; T-CELLS; IN-VIVO; CANCER-IMMUNOTHERAPY; BREAST-CANCER; FAMILY-MEMBER; ACTIVATION; INDUCTION; DEATH;
D O I：
10.4049/jimmunol.1000325
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dendritic cell (DC) apoptosis is an important event that regulates the balance between tolerance and immunity through multiple pathways, and defects in DC apoptosis can trigger autoimmunity. DC apoptosis is also associated with immunosuppression and has been observed under several pathologies and infections. Recent studies indicate that apoptotic DCs can also play an active role in induction of tolerance. This review discusses the regulatory pathways of DC apoptosis, stimuli inducing DC apoptosis, and the implications of DC apoptosis in the induction of immunosuppression and/or tolerance. The Journal of Immunology, 2010, 185: 795-802.
引用
收藏
页码：795 / 802
页数：8
相关论文
共 83 条
  • [1] Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs
    Albert, ML
    Sauter, B
    Bhardwaj, N
    [J]. NATURE, 1998, 392 (6671) : 86 - 89
  • [2] Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
    Albert, ML
    Pearce, SFA
    Francisco, LM
    Sauter, B
    Roy, P
    Silverstein, RL
    Bhardwaj, N
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (07) : 1359 - 1368
  • [3] Origin, precursors and differentiation of mouse dendritic cells
    Ardavín, C
    [J]. NATURE REVIEWS IMMUNOLOGY, 2003, 3 (07) : 582 - 590
  • [4] MHC class II-mediated apoptosis of mature dendritic cells proceeds by activation of the protein kinase C-δ isoenzyme
    Bertho, N
    Blancheteau, VM
    Setterblad, N
    Laupeze, B
    Lord, JM
    Drénou, B
    Amiot, L
    Charron, DJ
    Fauchet, R
    Mooney, N
    [J]. INTERNATIONAL IMMUNOLOGY, 2002, 14 (08) : 935 - 942
  • [5] Mechanisms of TRAIL-induced apoptosis in leukemic plasmacytoid dendritic cells
    Blum, Ariane
    Chaperota, Laurence
    Molens, Jean-Paul
    Foissaud, Vincent
    Plantaz, Dominique
    Plumas, Joel
    [J]. EXPERIMENTAL HEMATOLOGY, 2006, 34 (12) : 1655 - 1662
  • [6] Foxp3+ T Cells Induce Perforin-Dependent Dendritic Cell Death in Tumor-Draining Lymph Nodes
    Boissonnas, Alexandre
    Scholer-Dahirel, Alix
    Simon-Blancal, Virginie
    Pace, Luigia
    Valet, Fabien
    Kissenpfennig, Adrien
    Sparwasser, Tim
    Malissen, Bernard
    Fetler, Luc
    Amigorena, Sebastian
    [J]. IMMUNITY, 2010, 32 (02) : 266 - 278
  • [7] Prednisolone suppresses the function and promotes apoptosis of plasmacytoid dendritic cells
    Boor, P. P. C.
    Metselaar, H. J.
    Mancham, S.
    Tilanus, H. W.
    Kusters, J. G.
    Kwekkeboom, J.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (10) : 2332 - 2341
  • [8] Proapoptotic Bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    Bouillet, P
    Metcalf, D
    Huang, DCS
    Tarlinton, DM
    Kay, TWH
    Köntgen, F
    Adams, JM
    Strasser, A
    [J]. SCIENCE, 1999, 286 (5445) : 1735 - 1738
  • [9] The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth
    Cavassani, Karen A.
    Carson, William F.
    Moreira, Ana Paula
    Wen, Haitao
    Schaller, Matthew A.
    Ishii, Makoto
    Lindell, Dennis M.
    Dou, Yali
    Lukacs, Nicholas W.
    Keshamouni, Venkateshwar G.
    Hogaboam, Cory M.
    Kunkel, Steven L.
    [J]. BLOOD, 2010, 115 (22) : 4403 - 4411
  • [10] Dendritic cell apoptosis in the maintenance of immune tolerance
    Chen, M
    Wang, YH
    Wang, YH
    Huang, L
    Sandoval, H
    Liu, YJ
    Wang, J
    [J]. SCIENCE, 2006, 311 (5764) : 1160 - 1164
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