Isolation and characterization of a human putative receptor protein kinase cDNA STYK1

被引：23

作者：

Ye, X ^{[1
]}

Ji, CN ^{[1
]}

Huang, QS ^{[1
]}

Cheng, C ^{[1
]}

Tang, R ^{[1
]}

Xu, J ^{[1
]}

Zeng, L ^{[1
]}

Dai, JF ^{[1
]}

Wu, QH ^{[1
]}

Gu, SH ^{[1
]}

Xie, Y ^{[1
]}

Mao, YM ^{[1
]}

机构：

[1] Fudan Univ, Inst Genet, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2003年 / 30卷 / 02期

关键词：

protein kinase; receptor tyrosine kinase; signal pathway; STYK1; gene;

D O I：

10.1023/A:1023934017174

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinases (PKs) represent a well studied but most diverse protein superfamily. The covalent, reversible linkage of phosphate to serine, threonine, and tyrosine residues of substrate proteins by protein kinases is probably ubiquitous cellular mechanism for regulation of physiological processes. It is known to us that most signaling pathways impinge at some point on protein kinases. Here we report a human putative receptor protein kinase cDNA STYK1. The STYK1 cDNA is 2749 base pairs in length and contains an open reading frame encoding 422 amino acids. The STYK1 gene is mapped to human chromosome 12p13 and 11 exons were found. RT-PCR showed that STYK1 is widely expressed in human tissues.

引用

页码：91 / 96

页数：6

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