Effects of chronic taurine treatment on reactivity of the rat aorta

被引：36

作者：

Abebe, W ^{[1
]}

Mozaffari, MS ^{[1
]}

机构：

[1] Med Coll Georgia, Dept Oral Biol & Maxillofacial Pathol, Sch Dent, Augusta, GA 30912 USA

来源：

AMINO ACIDS | 2000年 / 19卷 / 3-4期

关键词：

amino acids; taurine; rat aorta; vascular reactivity; endothelium;

D O I：

10.1007/s007260070011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of chronic taurine treatment on the reactivity of the aorta form male Wistar-Kyoto rats were investigated. Contractile responses to norepinephrine (NE) and potassium chloride (KCl) were attenuated in aortic rings from taurine-treated rats as compared to controls both in the absence and presence of endothelium. However, the degree of attenuation was greater in endothelium-intact tissues contracted with NE. Acetylcholine (Ach)-induced relaxation responses were augmented in endothelium-intact vessels from rats supplemented with taurine compared to the responses observed in control preparations. Relaxation responses of the aortae from control and taurine-treated rats to sodium nitroprusside (SNP) were not different from each other. Our results suggest that taurine treatment attenuates vascular contractility nonspecifically and this effect is partly mediated via the endothelium.

引用

页码：615 / 623

页数：9

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