An improved preparation of arylboronates: Application in one-pot Suzuki biaryl synthesis

被引：109

作者：

Zhu, L ^{[1
]}

Duquette, J ^{[1
]}

Zhang, MB ^{[1
]}

机构：

[1] Bayer Res Ctr, Dept Chem Res, West Haven, CT 06516 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 09期

关键词：

D O I：

10.1021/jo0269114

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a modification of the Miyaura arylboronate synthesis(1a) by substituting a ligandless palladium catalyst for PdCl2(dppf). Palladium acetate, free of ligand, was found highly effective for such coupling reactions. This modified procedure is advantageous over the original Miyaura synthesis in ease of workup, catalyst removal, and low catalyst cost: Furthermore, the boronates formed in this manner can be used directly for Suzuki coupling reactions in a one-pot fashion. The biaryl products have improved impurity profiles and reduced heavy metal contamination.

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页码：3729 / 3732

页数：4

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