Voyage to minimal base editors

被引：0

作者：

Song, Beomjong ^{[1
]}

Bae, Sangsu ^{[2
,3
]}

机构：

[1] Hanyang Univ, Res Inst Convergence Basic Sci, Seoul, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Biochem & Mol Biol, Seoul, South Korea

来源：

NATURE CHEMICAL BIOLOGY | 2022年 / 18卷 / 09期

关键词：

BACTERIAL;

D O I：

10.1038/s41589-022-01101-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transposon-associated transposase B (TnpB) is the putative ancestor of Cas nucleases. A TnpB-based adenine base editor has now been developed that is small enough to be loaded into a single AAV vector without compromising editing activity.

引用

页码：920 / 921

页数：2

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