Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk

被引：32

作者：

Lecompte, Thomas

Wahl, Denis ^{[1
]}

Perret-Guillaume, Christine

Hemker, H. Coenraad

Lacolley, Patrick

Regnault, Veronique

机构：

[1] UHP, INSERM, U734, Fac Med, F-54500 Vandoeuvre Les Nancy, France

[2] Nancy Univ, UHP, Nancy, France

[3] Nancy Univ Hosp, Haematol Lab, Nancy, France

[4] Univ Maastricht, Synapse BV, CARIM, Maastricht, Netherlands

[5] INSERM, U684, Nancy, France

来源：

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2007年 / 92卷 / 05期

关键词：

antiphospholipid antibody; antiphospholipid syndrome; lupus anticoagulant; APC resistance; thrombin generation;

D O I：

10.3324/haematol.10577

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interference of antiphospholipid antibodies (aPL) with coagulation was investigated in 40 aPL-patients (24 with thrombosis) using thrombography. Impairment of the activated protein C anticoagulant pathway was partially offset by the genuine anticoagulant effect. The net result, a procoagulant phenotype, was associated with a 7-fold increased risk of thrombosis in aPL-patients.

引用

收藏

页码：714 / 715

页数：2

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