Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19

被引：29

作者：

Abraham, George R. ^{[1
,2
]}

Kuc, Rhoda E. ^{[2
]}

Althage, Magnus ^{[3
]}

Greasley, Peter J. ^{[3
]}

Ambery, Philip ^{[3
]}

Maguire, Janet J. ^{[2
]}

Wilkinson, Ian B. ^{[2
]}

Hoole, Stephen P. ^{[1
]}

Cheriyan, Joseph ^{[2
,4
,5
]}

Davenport, Anthony P. ^{[2
]}

机构：

[1] Royal Papworth Hosp NHS Fdn Trust, Papworth Rd,Cambridge Biomed Campus, Cambridge CB2 0AY, England

[2] Univ Cambridge, Addenbrookes Hosp, Div Expt Med & Immunotherapeut, Cambridge, England

[3] AstraZeneca, BioPharmaceut R&D, Renal & Metab CVRM, Late Stage Dev,Cardiovasc, Gothenburg, Sweden

[4] Cambridge Univ Hosp NHS Fdn Trust, Clin Pharmacol Dept, Cambridge, England

[5] Cambridge Univ Hosp NHS Fdn Trust, Cardiovasc Off, Cambridge Clin Trials Unit, Cambridge, England

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2022年 / 167卷

基金：

英国惠康基金;

关键词：

Endothelin-1; Covid-19; Endotheliitis; Endothelin receptor antagonists;

D O I：

10.1016/j.yjmcc.2022.03.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target.ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection.The results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients.

引用

页码：92 / 96

页数：5

共 19 条

[1] Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19
Ackermann, Maximilian
Verleden, Stijn E.
Kuehnel, Mark
Haverich, Axel
Welte, Tobias
Laenger, Florian
Vanstapel, Arno
Werlein, Christopher
Stark, Helge
Tzankov, Alexandar
Li, William W.
Li, Vincent W.
Mentzer, Steven J.
Jonigk, Danny
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (02) : 120 - 128
[2] A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development
Alexander, Steve P. H.
Armstrong, Jane F.
Davenport, Anthony P.
Davies, Jamie A.
Faccenda, Elena
Harding, Simon D.
Levi-Schaffer, Francesca
Maguire, Janet J.
Pawson, Adam J.
Southan, Christopher
Spedding, Michael
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 2020, 177 (21) : 4942 - 4966
[3] COVID-19-induced endotheliitis: emerging evidence and possible therapeutic strategies
Calabretta, Eleonora
Moraleda, Jose M.
Iacobelli, Massimo
Jara, Ruben
Vlodavsky, Israel
O'Gorman, Peter
Pagliuca, Antonio
Mo, Clifton
Baron, Rebecca M.
Aghemo, Alessio
Soiffer, Robert
Fareed, Jawed
Carlo-Stella, Carmelo
Richardson, Paul
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2021, 193 (01) : 43 - 51
[4] Chester Adrian H, 2014, Glob Cardiol Sci Pract, V2014, P62, DOI 10.5339/gcsp.2014.29
[5] Elevated endothelin concentrations are associated with reduced coronary vasomotor responses in patients with chest pain and normal coronary arteriograms
Cox, ID
Botker, HE
Bagger, JP
Sonne, HS
Kristensen, BO
Kaski, JC
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 34 (02) : 455 - 460
[6] Endothelin
Davenport, Anthony P.
Hyndman, Kelly A.
Dhaun, Neeraj
Southan, Christopher
Kohan, Donald E.
Pollock, Jennifer S.
Pollock, David M.
Webb, David J.
Maguire, Janet J.
[J]. PHARMACOLOGICAL REVIEWS, 2016, 68 (02) : 357 - 418
[7] Endothelin antagonism and sodium glucose Co-transporter 2 inhibition. A potential combination therapeutic strategy for COVID-19
Fisk, Marie
Althage, Magnus
Moosmang, Sven
Greasley, Peter J.
Cope, Andrew P.
Jayne, David R. W.
Galloway, James
Hall, Frances
Wilkinson, Ian B.
Ambery, Philip
Cheriyan, Joseph
[J]. PULMONARY PHARMACOLOGY & THERAPEUTICS, 2021, 69
[8] Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction
Ford, Thomas J.
Corcoran, David
Padmanabhan, Sandosh
Aman, Alisha
Rocchiccioli, Paul
Good, Richard
McEntegart, Margaret
Maguire, Janet J.
Watkins, Stuart
Eteiba, Hany
Shaukat, Aadil
Lindsay, Mitchell
Robertson, Keith
Hood, Stuart
McGeoch, Ross
McDade, Robert
Yii, Eric
Sattar, Naveed
Hsu, Li-Yueh
Arai, Andrew E.
Oldroyd, Keith G.
Touyz, Rhian M.
Davenport, Anthony P.
Berry, Colin
[J]. EUROPEAN HEART JOURNAL, 2020, 41 (34) : 3239 - +
[9] COVID-19 myocarditis: quantitative analysis of the inflammatory infiltrate and a proposed mechanism *
Fox, Sharon E.
Falgout, Lacey
Vander Heide, Richard S.
[J]. CARDIOVASCULAR PATHOLOGY, 2021, 54
[10] Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study
Goshua, George
Pine, Alexander B.
Meizlish, Matthew L.
Chang, C-Hong
Zhang, Hanming
Bahel, Parveen
Baluha, Audrey
Bar, Noffar
Bona, Robert D.
Burns, Adrienne J.
Dela Cruz, Charles S.
Dumont, Anne
Halene, Stephanie
Hwa, John
Koff, Jonathan
Menninger, Hope
Neparidze, Natalia
Price, Christina
Siner, Jonathan M.
Tormey, Christopher
Rinder, Henry M.
Chun, Hyung J.
Lee, Alfred, I
[J]. LANCET HAEMATOLOGY, 2020, 7 (08): : E575 - E582

← 1 2 →