Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats

被引：10

作者：

Wojewodzka-Zelezniakowicz, Marzena ^{[1
]}

Kisiel, Wioleta ^{[2
]}

Kramkowski, Karol ^{[2
]}

Gromotowicz-Poplawska, Anna ^{[2
]}

Zakrzeska, Agnieszka ^{[2
]}

Stankiewicz, Adrian ^{[2
]}

Kolodziejczyk, Patrycjusz ^{[2
]}

Szemraj, Janusz ^{[3
]}

Ladny, Jerzy Robert ^{[1
]}

Chabielska, Ewa ^{[2
]}

机构：

[1] Med Univ Bialystok, Dept Emergency & Disaster Med, Mickiewicza Str 2c, PL-15222 Bialystok, Poland

[2] Med Univ Bialystok, Dept Biopharm, Mickiewicza Str 2c, PL-15222 Bialystok, Poland

[3] Med Univ Lodz, Dept Med Biochem, Lodz, Poland

来源：

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | 2016年 / 17卷 / 02期

关键词：

Quinapril; propofol; rat; thrombosis; hypertension; CONVERTING-ENZYME-INHIBITOR; NITRIC-OXIDE SYNTHASE; ANGIOTENSIN-II; VASCULAR RELAXATION; VENOUS THROMBOSIS; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; MODEL; EXPRESSION; CAPTOPRIL;

D O I：

10.1177/1470320316647239

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Angiotensin converting enzyme inhibitors and propofol both exert hypotensive action and may affect hemostasis. We investigated the influence of quinapril and propofol on hemodynamics and hemostasis in renal-hypertensive rats with induced arterial thrombosis. Two-kidney, one clip hypertensive rats were treated with quinapril (3.0 mg/kg for 10 days), and then received propofol infusion (15 mg/kg/h) during ongoing arterial thrombosis. The hemodynamic and hemostatic parameters were assayed. Quinapril exerted a hypotensive effect increasing after propofol infusion. Quinapril showed an antithrombotic effect with the platelet adhesion reduction, fibrinolysis enhancement and oxidative stress reduction. Propofol did not influence thrombosis; however, it inhibited fibrinolysis and showed prooxidative action. The effect of propofol on fibrinolysis and oxidative stress was significantly lower in quinapril-pretreated rats. Mortality was increased among rats treated with both drugs together. Our study demonstrates that pretreatment with quinapril reduced the adverse effects of propofol on hemostasis. Unfortunately, co-administration of both drugs potentiated hypotension in rats, which corresponds to higher mortality.

引用

页数：12

共 74 条

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