A flow-based synthesis of Imatinib: the API of Gleevec

被引：150
|
作者：
Hopkin, Mark D. [1 ]
Baxendale, Ian R. [1 ]
Ley, Steven V. [1 ]
机构：
[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 14期
关键词：
POLYMER-SUPPORTED REAGENTS; ORGANIC-SYNTHESIS; PARALLEL; REACTOR; TOOLS;
D O I：
10.1039/c001550d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates.
引用
收藏
页码：2450 / 2452
页数：3
相关论文
共 50 条
  • [1] A Flow-Based Synthesis of Telmisartan
    Martin, Alex D.
    Siamaki, Ali R.
    Belecki, Katherine
    Gupton, B. Frank
    JOURNAL OF FLOW CHEMISTRY, 2015, 5 (03) : 145 - 147
  • [2] A Flow-Based Synthesis of Telmisartan
    Alex D. Martin
    Ali R. Siamaki
    Katherine Belecki
    B. Frank Gupton
    Journal of Flow Chemistry, 2015, 5 : 145 - 147
  • [3] API control flow-based next generation service creation environment
    Sueda, Y
    Miyake, J
    Niitsu, Y
    IEICE TRANSACTIONS ON COMMUNICATIONS, 2004, E87B (07) : 1918 - 1925
  • [4] Flow-based video synthesis and editing
    Bhat, KS
    Seitz, SM
    Hodgins, JK
    Khosla, PK
    ACM TRANSACTIONS ON GRAPHICS, 2004, 23 (03): : 360 - 363
  • [5] Imatinib Mesylate (Gleevec) Hepatotoxicity
    Ayse L. Mindikoglu
    Arie Regev
    Pablo A. Bejarano
    Enrique J. Martinez
    Lennox J. Jeffers
    Eugene R. Schiff
    Digestive Diseases and Sciences, 2007, 52 : 598 - 601
  • [6] Imatinib (Gleevec®)-induced hepatotoxicity
    Ayoub, WS
    Geller, SA
    Tran, T
    Martin, P
    Vierling, JM
    Poordad, FF
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 2005, 39 (01) : 75 - 77
  • [7] Imatinib mesylate (Gleevec) hepatotoxicity
    Mindikoglu, Ayse L.
    Regev, Arie
    Bejarano, Pablo A.
    Martinez, Enrique J.
    Jeffers, Lennox J.
    Schiff, Eugene R.
    DIGESTIVE DISEASES AND SCIENCES, 2007, 52 (02) : 598 - 601
  • [8] Rapid synthesis of glycosylated insulins by flow-based peptide synthesis
    Maki, Yuta
    Mong, Surin K.
    Chandrashekar, Chaitra
    Forbes, Briony E.
    Hossain, Mohammed Akhter
    Yamaguchi, Shintaro
    Fadzen, Colin M.
    Kajihara, Yasuhiro
    Pentelute, Bradley L.
    CHEMICAL SCIENCE, 2025,
  • [9] Hypopigmentation from imatinib mesylate (Gleevec)
    Grossman, WJ
    Wilson, DB
    JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2004, 26 (03) : 214 - 214
  • [10] Flow-based Methods in Chemical Peptide and Protein Synthesis
    Schiefelbein, Kevin
    Hartrampf, Nina
    CHIMIA, 2021, 75 (06) : 480 - 483
12345