A flow-based synthesis of Imatinib: the API of Gleevec

被引：152

作者：

Hopkin, Mark D. ^{[1
]}

Baxendale, Ian R. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 14期

关键词：

POLYMER-SUPPORTED REAGENTS; ORGANIC-SYNTHESIS; PARALLEL; REACTOR; TOOLS;

D O I：

10.1039/c001550d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates.

引用

页码：2450 / 2452

页数：3

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