Rubratoxin C, a new nonadride derivative from an endophytic fungus Penicillium sp F-14

被引：13
作者：
Chen, Ri-Dao [1 ,2 ]
Yan, Zheng [1 ,2 ]
Zou, Jian-Hua [1 ,2 ]
Wang, Nan [1 ,2 ]
Dai, Jun-Gui [1 ,2 ]
机构：
[1] Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[2] Chinese Acad Med Sci, Beijing 100050, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2014年 / 25卷 / 09期
关键词：
Nonadride derivative; Endophytic fungus; Natural products; Cytotoxic activity; ABSOLUTE-CONFIGURATIONS; PERICONIA SP; A-C; METABOLITES; THIODIKETOPIPERAZINES;
D O I：
10.1016/j.cclet.2014.03.040
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
One new nonadride derivative rubratoxin C (1) together with a known compound rubratoxin B (2) were isolated from an endophytic fungus Penicillium sp. F-14. Their structures were elucidated by various spectroscopic methods. Bioassays showed that 2 had moderate cytotoxic effect against HCT-8, BEL-7402, Ketr3, A2780, MCF-7 and BGC-823 human cancer cell lines, and 1 exhibited weak activity. (C) 2014 Jun-Gui Dai. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：1308 / 1310
页数：3
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