Evaluation of stool antigen detection for diagnosis of Helicobacter pylori infection in adults

被引:5
作者
Aguemon, B
Struelens, M
Deviere, J
Denis, O
Golstein, P
Nagy, N
Salmon, I
机构
[1] Free Univ Brussels, Sch Publ Hlth, Dept Infect Dis, Epidemiol Unit,Dept Microbiol, B-1070 Brussels, Belgium
[2] Erasme Univ Hosp, Dept Gastroenterol & Hepatol, B-1070 Brussels, Belgium
[3] Erasme Univ Hosp, Dept Anat Pathol, B-1070 Brussels, Belgium
关键词
Helicobacter pylori; diagnosis; antigen detection test; ulcer disease;
D O I
10.1179/acb.2004.036
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: The aims of this study were to evaluate the performance of Helicobacter pylori stool antigen test in the diagnosis of H. pylori infection. Method. The study included 63 out patients attending the ULB-Lothier Clinic between January 1 and July 31, 2002. They underwent an upper endoscopy, as well as biopsies for histological examination and for culture of H. pylori. Stool samples of these patients were collected either the day of the endoscopy or within 24 hours and tested for H. pylori antigen (HpSA Test) Results: The mean age of study patients included 29 men and 34 women was 51(+/- :16) years. H. pylori infection was detected in 29 cases (46%) by culture and histology, and in 31 cases (49.2%) by detection of the antigen in the feces. In 27 patients, all methods were positive whereas 5 in they provided discrepant results. Compared to the reference methods (culture and histology), the HpSA test had a sensitivity of 96.5% and a specificity of 91.2%. PPV of 90.3% and NPV of 96.8%. Conclusion: The good correlation found between the results of the HpSA test and the methods based on endoscopy supports its use as an alternative to invasive methods of diagnosis of H. pylori infection and therapeutic follow-up.
引用
收藏
页码:246 / 250
页数:5
相关论文
共 31 条
[1]  
Altindis M, 2002, ACTA GASTRO-ENT BELG, V65, P74
[2]   Stool antigen assay (HpSA) is less reliable than urea breath test for post-treatment diagnosis of Helicobacter pylori infection [J].
Bilardi, C ;
Biagini, R ;
Dulbecco, P ;
Iiritano, E ;
Gambaro, C ;
Mele, MR ;
Borro, P ;
Tessieri, L ;
Zentilin, P ;
Mansi, C ;
Vigneri, S ;
Savarino, V .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2002, 16 (10) :1733-1738
[3]  
Bommelaer G, 2001, GASTROEN CLIN BIOL, V25, P1084
[4]   Comparison of new faecal antigen test with 13C-urea breath test for detecting Helicobacter pylori infection and monitoring eradication treatment:: prospective clinical evaluation [J].
Braden, B ;
Teuber, G ;
Dietrich, CF ;
Caspary, WF ;
Lembcke, B .
BRITISH MEDICAL JOURNAL, 2000, 320 (7228) :148-148
[5]   New immunoassay in stool provides an accurate noninvasive diagnostic method for Helicobacter pylori screening in children [J].
Braden, B ;
Posselt, HG ;
Ahrens, P ;
Kitz, R ;
Dietrich, CF ;
Caspary, WF .
PEDIATRICS, 2000, 106 (01) :115-117
[6]  
Bravo LE, 1999, AM J GASTROENTEROL, V94, P2380, DOI 10.1111/j.1572-0241.1999.01361.x
[7]  
BROUTET N, 2000, LETT INFECT S3, P28
[8]  
Caselli M, 1999, LANCET, V354, P1209, DOI 10.1016/S0140-6736(05)75418-0
[9]  
DOUGLAS J, 1999, AM J GASTROENTEROL, V94, P2380
[10]  
Ishihara S, 2000, ALIMENT PHARM THER, V14, P611