Antibacterial Compounds from Mushrooms II: Lanostane Triterpenoids and an Ergostane Steroid with Activity Against Bacillus cereus Isolated from Fomitopsis pinicola

被引：41

作者：

Liu, Xue-Ting ^{[1
]}

Winkler, Abby L.

Schwan, William R.

Volk, Thomas J.

Rott, Marc ^{[2
]}

Monte, Aaron ^{[1
]}

机构：

[1] Univ Wisconsin La Crosse, Dept Chem, La Crosse, WI 54601 USA

[2] Univ Wisconsin La Crosse, Dept Microbiol, La Crosse, WI 54601 USA

来源：

PLANTA MEDICA | 2010年 / 76卷 / 05期

基金：

美国国家科学基金会;

关键词：

antibacterial activity; Fomitopsis pinicola (Polyporaceae); lanostane triterpenoid; ergostane steroid; Bacillus cereus;

D O I：

10.1055/s-0029-1186227

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Anti-Bacillus cereus bioassay-guided fractionation of a crude extract of the American mushroom, Fomitopsis pinicola, was performed using thin-layer chromatography, Sephadex LH-20 column chromatography, and preparative-scale HPLC. Five lanostane triterpenoids (1-5) and one ergostane steroid (6) were isolated and identified. Compound 1 is a new lanostane triterpenoid, and its structure was determined using 1D and 2D NMR experiments, HR-MS, and physical data. Each of the purified compounds (1-6) was tested for antibacterial activity against B. cereus using standard MIC assays. Compounds 1-6 had MIC values of 32, 16, 32, 32, 128, and 64 mu g/mL, respectively.

引用

页码：464 / 466

页数：3

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