Deep tissue imaging with multiphoton fluorescence microscopy

被引：118

作者：

Miller, David R. ^{[1
]}

Jarrett, Jeremy W. ^{[1
]}

Hassan, Ahmed M. ^{[1
]}

Dunn, Andrew K. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Biomed Engn, 107 W Dean Keeton C0800, Austin, TX 78712 USA

来源：

CURRENT OPINION IN BIOMEDICAL ENGINEERING | 2017年 / 4卷

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Multiphoton microscopy fluorescence imaging; Scattering and absorption in brain tissue; Laser sources for multiphoton microscopy; Fluorophores for multiphoton microscopy;

D O I：

10.1016/j.cobme.2017.09.004

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We present a review of imaging deep-tissue structures with multiphoton microscopy. We examine the effects of light scattering and absorption due to the optical properties of biological sample and identify 1300 nm and 1700 nm as ideal excitation wavelengths. We summarize the availability of fluorophores for multiphoton microscopy as well as ultrafast laser sources to excite available fluorophores. Lastly, we discuss the applications of multiphoton microscopy for neuroscience.

引用

页码：32 / 39

页数：8

共 51 条

[1] Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging [J].

Akerboom, Jasper ;

Chen, Tsai-Wen ;

Wardill, Trevor J. ;

Tian, Lin ;

Marvin, Jonathan S. ;

Mutlu, Sevinc ;

Calderon, Nicole Carreras ;

Esposti, Federico ;

Borghuis, Bart G. ;

Sun, Xiaonan Richard ;

Gordus, Andrew ;

Orger, Michael B. ;

Portugues, Ruben ;

Engert, Florian ;

Macklin, John J. ;

Filosa, Alessandro ;

Aggarwal, Aman ;

Kerr, Rex A. ;

Takagi, Ryousuke ;

Kracun, Sebastian ;

Shigetomi, Eiji ;

Khakh, Baljit S. ;

Baier, Herwig ;

Lagnado, Leon ;

Wang, Samuel S. -H. ;

Bargmann, Cornelia I. ;

Kimmel, Bruce E. ;

Jayaraman, Vivek ;

Svoboda, Karel ;

Kim, Douglas S. ;

Schreiter, Eric R. ;

Looger, Loren L. .

JOURNAL OF NEUROSCIENCE, 2012, 32 (40) :13819-13840

[2] Two-Photon Optical Properties of Near-Infrared Dyes at 1.55 μm Excitation [J].

Berezin, Mikhail Y. ;

Zhan, Chun ;

Lee, Hyeran ;

Joo, Chulmin ;

Akers, Walter J. ;

Yazdanfar, Siavash ;

Achilefu, Samuel .

JOURNAL OF PHYSICAL CHEMISTRY B, 2011, 115 (39) :11530-11535

[3] A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research [J].

Bianchi, Roberta ;

Teijeira, Alvaro ;

Proulx, Steven T. ;

Christiansen, Ailsa J. ;

Seidel, Catharina D. ;

Ruelicke, Thomas ;

Maekinen, Taija ;

Haegerling, Rene ;

Halin, Cornelia ;

Detmar, Michael .

PLOS ONE, 2015, 10 (04)

[4] Ultrasensitive fluorescent proteins for imaging neuronal activity [J].

Chen, Tsai-Wen ;

Wardill, Trevor J. ;

Sun, Yi ;

Pulver, Stefan R. ;

Renninger, Sabine L. ;

Baohan, Amy ;

Schreiter, Eric R. ;

Kerr, Rex A. ;

Orger, Michael B. ;

Jayaraman, Vivek ;

Looger, Loren L. ;

Svoboda, Karel ;

Kim, Douglas S. .

NATURE, 2013, 499 (7458) :295-+

[5] Sensitive red protein calcium indicators for imaging neural activity [J].

Dana, Hod ;

Mohar, Boaz ;

Sun, Yi ;

Narayan, Sujatha ;

Gordus, Andrew ;

Hasseman, Jeremy P. ;

Tsegaye, Getahun ;

Holt, Graham T. ;

Hu, Amy ;

Walpita, Deepika ;

Patel, Ronak ;

Macklin, John J. ;

Bargmann, Cornelia I. ;

Ahrens, Misha B. ;

Schreiter, Eric R. ;

Jayaraman, Vivek ;

Looger, Loren L. ;

Svoboda, Karel ;

Kim, Douglas S. .

ELIFE, 2016, 5

[6] 2-PHOTON LASER SCANNING FLUORESCENCE MICROSCOPY [J].

DENK, W ;

STRICKLER, JH ;

WEBB, WW .

SCIENCE, 1990, 248 (4951) :73-76

[7]

Drobizhev M, 2011, NAT METHODS, V8, P393, DOI [10.1038/NMETH.1596, 10.1038/nmeth.1596]

[8] Oxygen microscopy by two-photon-excited phosphorescence [J].

Finikova, Olga S. ;

Lebedev, Artem Y. ;

Aprelev, Alexey ;

Troxler, Thomas ;

Gao, Feng ;

Garnacho, Carmen ;

Muro, Silvia ;

Hochstrasser, Robin M. ;

Vinogradov, Sergei A. .

CHEMPHYSCHEM, 2008, 9 (12) :1673-1679

[9] In vivo near-infrared fluorescence imaging [J].

Frangioni, JV .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2003, 7 (05) :626-634

[10] Quantifying the Microvascular Origin of BOLD-fMRI from First Principles with Two-Photon Microscopy and an Oxygen-Sensitive Nanoprobe [J].

Gagnon, Louis ;

Sakadzic, Sava ;

Lesage, Frederic ;

Musacchia, Joseph J. ;

Lefebvre, Joel ;

Fang, Qianqian ;

Yuecel, Meryem A. ;

Evans, Karleyton C. ;

Mandeville, Emiri T. ;

Cohen-Adad, Juelien ;

Polimeni, Jonaethan R. ;

Yaseen, Mohammad A. ;

Lo, Eng H. ;

Greve, Douglas N. ;

Buxton, Richard B. ;

Dale, Anders M. ;

Devor, Anna ;

Boas, David A. .

JOURNAL OF NEUROSCIENCE, 2015, 35 (08) :3663-3675

← 1 2 3 4 5 6 →