An upconversion nanoparticle/Ru(II) polypyridyl complex assembly for NIR-activated release of a DNA covalent-binding agent

被引：17

作者：

Chen, Yumeng ^{[1
,2
]}

Jiang, Guoyu ^{[1
]}

Zhou, Qianxiong ^{[1
]}

Zhang, Yangyang ^{[1
,2
]}

Li, Ke ^{[1
,2
]}

Zheng, Yue ^{[1
,2
]}

Zhang, Baowen ^{[1
]}

Wang, Xuesong ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 28期

关键词：

PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS; FLUORESCENCE; NANOPLATFORM; RUTHENIUM; PORPHYRIN; CHLORIDE;

D O I：

10.1039/c6ra03396b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photoactivated anticancer chemotherapy distinguishes itself by its high selectivity by virtue of the spatiotemporal control of irradiation. However, short photoactivation wavelengths limit its application. Herein, an amphiphilic Ru(II) complex, cis-[Ru(bpy)(2)(C18H37CN)(2)](2+) (bpy = 2,2'-bipyridine), was embedded along with a poly(ethylene glycol, PEG)-modified lipid onto the surfaces of oleate-capped lanthanide-doped upconversion nanoparticles (UCNPs). The resultant core-shell hybrid system is water-dispersible, stable in the dark, and releases a DNA covalent-binding agent of [Ru(bpy)(2)(H2O)(2)](2+) upon 980 nm laser irradiation, providing guidelines for developing near-infrared (NIR) light triggered chemotherapeutics.

引用

页码：23804 / 23808

页数：5

共 53 条

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