Nanotechnology in pulmonary medicine

被引：74

作者：

Doroudian, Mohammad ^{[1
,2
,3
]}

O'Neill, Andrew ^{[1
,2
]}

Mac Loughlin, Ronan ^{[4
,5
,6
]}

Prina-Mello, Adriele ^{[7
,8
,9
,10
]}

Volkov, Yuri ^{[7
,8
,9
,10
,11
]}

Donnelly, Seamas C. ^{[1
,2
]}

机构：

[1] Tallaght Univ Hosp, Dept Med, Dublin, Ireland

[2] Trinity Coll Dublin, Dublin, Ireland

[3] Kharazmi Univ, Fac Biol Sci, Dept Cell & Mol Sci, Tehran, Iran

[4] IDA Business Pk, Aerogen, Galway, Ireland

[5] Royal Coll Surg, Sch Pharm & Biomol Sci, Dublin, Ireland

[6] Trinity Coll Dublin, Sch Pharm & Pharmaceut Sci, Dublin, Ireland

[7] Trinity Coll Dublin, Dept Med, Lab Biol Characterizat Adv Mat LBCAM, Dublin, Ireland

[8] Trinity Coll Dublin, Trinity Translat Med Inst TTMI, Nanomed Grp, Dublin, Ireland

[9] Trinity Coll Dublin, CRANN Inst, Dublin, Ireland

[10] Trinity Coll Dublin, AMBER Ctr, Dublin, Ireland

[11] First Moscow State Sechenov Med Univ, Dept Histol Cytol & Embryol, Moscow, Russia

来源：

CURRENT OPINION IN PHARMACOLOGY | 2021年 / 56卷

基金：

爱尔兰科学基金会;

关键词：

DRUG-DELIVERY; LUNG-CANCER; CO-DELIVERY; NANOPARTICLES; CHEMOTHERAPY; RELEASE;

D O I：

10.1016/j.coph.2020.11.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanotechnology in medicine?nanomedicine?is extensively employed to diagnose, treat, and prevent pulmonary diseases. Over the last few years, this brave new world has made remarkable progress, offering opportunities to address historical clinical challenges in pulmonary diseases including multi drug resistance, adverse side effects of conventional therapeutic agents, novel imaging, and earlier disease detection. Nanomedicine is also being applied to tackle the new emerging infectious diseases, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), influenza A virus subtype H1N1 (A/H1N1), and more recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this review we provide both a historical overview of the application of nanomedicine to respiratory diseases and more recent cutting-edge approaches such as nanoparticle-mediated combination therapies, novel double-targeted nondrug delivery system for targeting, stimuli-responsive nanoparticles, and theranostic imaging in the diagnosis and treatment of pulmonary diseases.

引用

页码：85 / 92

页数：8

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