Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain Forest

被引：41

作者：

Cao, Shugeng

Brodie, Peggy J.

Miller, James S.

Ratovoson, Fidy

Birkinshaw, Chris

Randrianasolo, Sennen

Rakotobe, Etienne

Rasamison, Vincent E.

Kingston, David G. I.

机构：

[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA

[2] Missouri Bot Garden, St Louis, MO 63166 USA

[3] Ctr Natl Applicat & Rech Pharmaceut, Antananarivo 101, Madagascar

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 04期

关键词：

D O I：

10.1021/np070004i

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of the ethanol extract obtained from the fruits of Rheedia calcicola led to the isolation of two new guttiferone analogues, guttiferones K (1) and L (16-hydroxyguttiferone K) (2). The structures of 1 and 2 were established on the basis of extensive interpretation of one- and two-dimensional NMR spectroscopic data. Both compounds were tested for their antiproliferative activity against the A2780 human ovarian cancer cell line.

引用

页码：686 / 688

页数：3

共 23 条

[1]

Alves TMD, 1999, J NAT PROD, V62, P369, DOI 10.1021/np9803833

[2] Bioactive benzophenones from Garcinia xanthochymus fruits [J].

Baggett, S ;

Protiva, P ;

Mazzola, EP ;

Yang, H ;

Ressler, ET ;

Basile, MJ ;

Weinstein, IB ;

Kennelly, EJ .

JOURNAL OF NATURAL PRODUCTS, 2005, 68 (03) :354-360

[3] CHEMICAL INVESTIGATION OF THE GENUS RHEEDIA .5. BIFLAVONOIDS AND XANTHOCHYMOL [J].

BOTTA, B ;

MACQUHAE, MM ;

DELLEMONACHE, G ;

DELLEMONACHE, F ;

DEMELLO, JF .

JOURNAL OF NATURAL PRODUCTS, 1984, 47 (06) :1053-1053

[4] Antiproliferative xanthones of Terminalia calcicola from the Madagascar rain forest [J].

Cao, Shugeng ;

Brodie, Peggy J. ;

Miller, James S. ;

Randrianaivo, Richard ;

Ratovoson, Fidy ;

Birkinshaw, Chris ;

Andriantsiferana, Rabodo ;

Rasamison, Vincent E. ;

Kingston, David G. I. .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (04) :679-681

[5]

DELLEMONACHE G, 1984, PHYTOCHEMISTRY, V23, P1757

[6]

DELLEMONACHE G, 1984, J NAT PROD, V47, P620

[7]

DELLEMONACHE G, 1983, J NAT PROD, V46, P655

[8] Complete assignment of the 1H and 13C NMR spectra of the tetraisoprenylated benzophenone 15-epiclusianone [J].

dos Santos, MH ;

Nagem, TJ ;

Braz Filho, R ;

Lula, IS ;

Speziali, NL .

MAGNETIC RESONANCE IN CHEMISTRY, 2001, 39 (03) :155-159

[9] HIV INHIBITORY NATURAL-PRODUCTS .8. THE GUTTIFERONES, HIV-INHIBITORY BENZOPHENONES FROM SYMPHONIA-GLOBULIFERA, GARCINIA-LIVINGSTONEI GARCINIA-OVALIFOLIA AND CLUSIA-ROSEA [J].

GUSTAFSON, KR ;

BLUNT, JW ;

MUNRO, MHG ;

FULLER, RW ;

MCKEE, TC ;

CARDELLINA, JH ;

MCMAHON, JB ;

CRAGG, GM ;

BOYD, MR .

TETRAHEDRON, 1992, 48 (46) :10093-10102

[10] Oblongifolins A-D, polyprenylated benzoylphloroglucinol derivatives from Garcinia oblongifolia [J].

Hamed, Wafaa ;

Brajeul, Solenn ;

Mahuteau-Betzer, Florence ;

Thoison, Odile ;

Mons, Stephane ;

Delpech, Bernard ;

Van Hung, Nguyen ;

Sevenet, Thierry ;

Marazano, Christian .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (05) :774-777

← 1 2 3 →