New Insight of Tumor Microenvironment in Non-Small Cell Lung Cancer

被引:2
|
作者
Sever, Tolga [1 ]
Leblebici, Asim [1 ]
Koc, Altug [1 ,2 ]
Binicier, Cilem [1 ]
Olgun, Aybuke [1 ,3 ]
Edizer, Deniz Tuna [1 ,4 ]
Ozdemir, Taha Resid [5 ,6 ]
Serin, Gurdeniz [5 ,7 ]
Erdem, Melek [5 ,8 ]
Basbinar, Yasemin [9 ]
机构
[1] Dokuz Eylul Univ, Inst Hlth Sci, Dept Oncol, Translat Oncol, Izmir, Turkey
[2] Dokuz Eylul Univ, Fac Med, Med Genet, Izmir, Turkey
[3] Izmir Tepecik Training & Res Hosp, Internal Med, Izmir, Turkey
[4] Bozyaka Training & Res Hosp, Dept Ear Nose & Throat, Izmir, Turkey
[5] Dokuz Eylul Univ, Dept Oncol, Basic Oncol, Inst Hlth Sci, Izmir, Turkey
[6] Izmir Tepecik Training & Res Hosp, Genet Diagnost Ctr, Izmir, Turkey
[7] Ege Univ, Fac Med, Pathol, Izmir, Turkey
[8] Behcet Uz Child Dis & Pediat Surg Training & Res, Pediat Hematol & Oncol, Izmir, Turkey
[9] Dokuz Eylul Univ, Inst Oncol, Dept Translat Oncol, Izmir, Turkey
来源
关键词
Tumor Microenvironment; Non-Small Cell Lung Cancer; Extracellular Matris; TERTIARY LYMPHOID STRUCTURES; REGULATORY T-CELLS; PROGNOSTIC VALUE; FIBROBLASTS; METASTASIS; SURVIVAL; ANGIOGENESIS; INFLAMMATION; PROGRESSION; EXPRESSION;
D O I
10.30621/jbachs.2019.625
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
As in all living cells, cancer cells are evaluating is very important in the frames of tumor development and treatment. As in all evolutionary process, the environment of living cells has an important role. Tumor cells have an environment is called tumor microenvironment, affects the therapeutic response and clinical results. Tumor microenvironments involve various cell types, extracellular matrix substances that are in the niche of cancer cells. The microenvironment is not only important in tumorigenesis but it is effective on therapeutic efficacy. In this review, we carried out the interaction between non-small cell lung cancer and its microenvironment to point out the significance of the tumor environment.
引用
收藏
页码:113 / 120
页数:8
相关论文
共 50 条
  • [1] Clinical significance of the tumor microenvironment in non-small cell lung cancer
    Shimizu, Katsuhiko
    Okita, Riki
    Nakata, Masao
    ANNALS OF TRANSLATIONAL MEDICINE, 2013, 1 (02)
  • [2] Radiation and Modulation of the Tumor Immune Microenvironment in Non-Small Cell Lung Cancer
    Goff, Peter H.
    Zeng, Jing
    Rengan, Ramesh
    Schaub, Stephanie K.
    SEMINARS IN RADIATION ONCOLOGY, 2021, 31 (02) : 133 - 139
  • [3] Characterization of the tumor microenvironment and immune profile in non-small cell lung cancer
    Ackermann, Andreas
    Musa, Hanny
    Zimmermann, Johannes
    Segerer, Felix
    Widmaier, Moritz
    Andrulis, Mindaugas
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [4] The tumor immune microenvironment at different stages of non-small cell lung cancer
    Hansen, Mackenzie
    Zhou, Qin
    DeRose, Yoko S.
    Kovacsovics, Magdalena
    Brintz, Benjamin
    Witt, Benjamin L.
    O'Neill, Kim L.
    Hu-Lieskovan, Siwen
    CANCER RESEARCH, 2024, 84 (06)
  • [5] Cancer-associated fibroblasts and the tumor microenvironment in non-small cell lung cancer
    Suzuki, Jun
    Tsuboi, Masahiro
    Ishii, Genichiro
    EXPERT REVIEW OF ANTICANCER THERAPY, 2022, 22 (02) : 169 - 182
  • [6] New evaluation of the tumor immune microenvironment of non-small cell lung cancer and its association with prognosis
    Shinohara, Shuichi
    Takahashi, Yusuke
    Komuro, Hiroyasu
    Matsui, Takuya
    Sugita, Yusuke
    Demachi-Okamura, Ayako
    Muraoka, Daisuke
    Takahara, Hirotomo
    Nakada, Takeo
    Sakakura, Noriaki
    Masago, Katsuhiro
    Miyai, Manami
    Nishida, Reina
    Shomura, Shin
    Shigematsu, Yoshiki
    Hatooka, Shunzo
    Sasano, Hajime
    Watanabe, Fumiaki
    Adachi, Katsutoshi
    Fujinaga, Kazuya
    Kaneda, Shinji
    Takao, Motoshi
    Ohtsuka, Takashi
    Yamaguchi, Rui
    Kuroda, Hiroaki
    Matsushita, Hirokazu
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (04)
  • [7] Dendritic Cell Vaccination in Non-Small Cell Lung Cancer: Remodeling the Tumor Immune Microenvironment
    Abascal, Jensen
    Oh, Michael S.
    Liclican, Elvira L.
    Dubinett, Steven M.
    Salehi-Rad, Ramin
    Liu, Bin
    CELLS, 2023, 12 (19)
  • [8] Analysis of the immunological microenvironment at the tumor site in patients with non-small cell lung cancer
    Rui Li
    Dominik Rüttinger
    Rong Li
    Lü-Sheng Si
    Yi-Li Wang
    Langenbeck's Archives of Surgery, 2003, 388 : 406 - 412
  • [9] Tumor microenvironment (TME) of HRAS mutated non-small cell lung cancer (NSCLC)
    Trabolsi, A.
    Rodriguez, E.
    Kareff, S.
    Gallegos, J. A. Ocejo
    Yin, J.
    Walker, P.
    Mamdani, H.
    Nieva, J. J.
    Borghaei, H.
    Nabhan, C.
    Nagasaka, M.
    Puri, S.
    Liu, S. V.
    Halmos, B.
    Lopes, G.
    ANNALS OF ONCOLOGY, 2022, 33 (07) : S1041 - S1041
  • [10] Changes of tumor microenvironment in non-small cell lung cancer after TKI treatments
    Chen, Shanshan
    Tang, Jingyi
    Liu, Fen
    Li, Wei
    Yan, Ting
    Shangguan, Dangang
    Yang, Nong
    Liao, Dehua
    FRONTIERS IN IMMUNOLOGY, 2023, 14